Antimicrobial peptides (Temporin A and Iseganan IB-367): effect on the cysticerci of Taenia crassiceps

Molecular and Biochemical Parasitology
Abraham LandaWojciech Kamysz

Abstract

Taenia solium infections continue being a health problem in undeveloped countries, and few effective control measures against this parasite are being applied. Antimicrobial peptides (AMPs) belong to the innate immune response and capable of destroying pathogens. We tested the ability of two AMPs, Temporin A (TA) and Iseganan IB-367 (IB-367) to damage T. crassiceps cysticerci in vitro. Doses of 200 and 400 microg/ml of TA and IB-367 caused cysticerci to shrink, lose motility, the formation of macrovesicles in the tegument, as well as decreased evagination properties. These changes were observed as early as 3-6h and became more pronounced over 24h, when the morphological changes of the bladders became evident by both light and electron microscopy. Electron micrographs of cysticerci exposed to peptides showed initial changes as collapsed microvesicles in the tegument, with formation of large vesicles and extrusion of tegumentary tissues into the surrounding media, which led to complete loss of the tegument as well as shrinkage and complete loss of structure of parenchymal tissue after 24h. Peptides administered to cysticercotic mice one month post-infection in a single intraperitoneal dose of 200 or 400 microg, reduced the parasit...Continue Reading

References

Jan 1, 1989·Bio Systems·L F Jiménez-GarcíaG H Vázquez-Nin
May 20, 1999·Biopolymers·D Andreu, L Rivas
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·R E Hancock, M G Scott
Jan 6, 2001·Critical Reviews in Immunology·M G Scott, R E Hancock
Mar 26, 2004·The Journal of Parasitology·Mary E EverhartDerek A Zelmer
May 25, 2004·Antimicrobial Agents and Chemotherapy·Francisca PalomaresHelgi Jung Cook
Mar 31, 2006·Cellular and Molecular Life Sciences : CMLS·M L Mangoni

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Citations

Oct 20, 2009·Parasitology·Kaethe Willms, Rimma Zurabian
Aug 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Angélique LewiesDu Plessis Lissinda Hester
Jun 24, 2016·Experimental Parasitology·Aline A FreitasRuy S Lino-Júnior
Jun 18, 2016·FEBS Letters·David Flores-SolisFederico Del Rio-Portilla
Apr 4, 2017·Expert Opinion on Biological Therapy·Josep M SierraMiguel Viñas
Oct 20, 2020·Frontiers in Immunology·Derry K Mercer, Deborah A O'Neil

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