Antimicrobial peptides with unusual amino acid compositions and unusual structures

Current Medicinal Chemistry
N Sitaram

Abstract

Antimicrobial peptides, which constitute an important component of innate immunity in animal and plant kingdom, are ubiquitously distributed in nature. However, they differ widely in their sizes, sequences and structures. On the basis of their structure they have been broadly classified into three classes: a) linear peptides with propensity for amphiphilic alpha-helical structure, b) peptides with beta or alphabeta structure stabilized by different number of disulfide bridges and c) peptides with over-representation of certain amino acids or unusual structures. Although considerable amount of work has been done on peptides of all the three classes, recent reviews have emphasized on peptides belonging to the first two classes. The present review focuses on the peptides belonging to the third group. The antimicrobial peptides discussed in this article include aromatic amino acid-rich peptides, (Pro-Arg)-rich peptides, unusual defensins and defensin-like molecules, unusual antimicrobial peptides from amphibians, bacteriocins with unusual structure and anionic antimicrobial peptides.

Citations

Apr 12, 2013·Biofouling·M C Ammons, V Copié
Nov 19, 2015·Pharmaceuticals·James P TamWei Liang Tan
Aug 26, 2010·Regulatory Peptides·Sung-Hee LeeHyung-Sik Won
Apr 25, 2007·Magnetic Resonance Imaging·Nikolaus WeiskopfKlaus Mathiak
Jun 23, 2009·Journal of Peptide Science : an Official Publication of the European Peptide Society·Su-Jin KangBong-Jin Lee
Dec 9, 2008·Biochimica Et Biophysica Acta·Hyung-Sik WonBong-Jin Lee
Jan 3, 2012·Chemistry and Physics of Lipids·José Carlos BozelliShirley Schreier
Jun 19, 2012·Biochimica Et Biophysica Acta·Agnieszka Zdybicka-BarabasMałgorzata Cytryńska
Aug 10, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K V K MohanC D Atreya
Jun 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bethany AlgayerThomas J Tucker
Jun 1, 2011·Probiotics and Antimicrobial Proteins·Leonard T NguyenHans J Vogel
Aug 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nicholas G FischerConrado Aparicio
Jul 9, 2011·Organic & Biomolecular Chemistry·Abdelatif ElMarrouniMontserrat Heras
Jan 19, 2020·Biochimica Et Biophysica Acta. Biomembranes·Gopal PanditSunanda Chatterjee
Apr 30, 2021·Botanical Studies·Junpeng LiXingyong Yang
Jul 14, 2010·Journal of Medicinal Chemistry·María Fernández-ReyesLuis Rivas
Jul 6, 2021·Frontiers in Chemistry·Tanumoy SarkarSunanda Chatterjee
Aug 3, 2018·Journal of Medicinal Chemistry·Gopal PanditSunanda Chatterjee

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