Antimicrobial photodynamic therapy associated with tissue regeneration for peri-implantitis: A case report

Photodiagnosis and Photodynamic Therapy
Gabriel Garcia de CarvalhoDaniela Leal Zandim-Barcelos

Abstract

Antimicrobial photodynamic therapy (aPDT) has emerged as a promising alternative to promote bacteria elimination and crestal bone remodeling in patients affected by peri-implantitis, once it is able to access the implant microstructure at the most restricted sites with no damage to implant surface. This paper reports a 6-month follow-up of a patient with peri-implantitis treated by surgical approach with adjunct photodynamic therapy associated to guided bone regeneration. A full thickness open-flap was performed to allow directly mechanical debridement, followed by aPDT using methylene blue 200 µg/mL under red laser irradiation (660 nm, 100 mW, 9 J), providing decontamination of implant surface and surrounding tissue. Photosensitizer was washed twice with saline solution previously to guided bone regeneration, which was carried out using xenogeneic bone and resorbable collagen membrane. After 6-month follow-up, the use of aPDT as an adjunct therapy to tissue regeneration for peri-implantitis promoted sufficient decontamination, clear evidence of bone regeneration, and peri-implant health restoration.

References

May 2, 2009·Journal of Dental Research·T W OatesC A McMahan
Nov 15, 2013·Implant Dentistry·Gian Paolo BombeccariFrancesco Spadari
Jun 22, 2018·Journal of Clinical Periodontology·Frank SchwarzHom-Lay Wang
Jun 22, 2018·Journal of Clinical Periodontology·Mauricio G Araujo, Jan Lindhe
Nov 16, 2018·Photodiagnosis and Photodynamic Therapy·Tsun-Chin HuangChun-Cheng Chen

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Citations

Sep 4, 2020·European Journal of Dentistry·Dinesh RokayaPasutha Thunyakitpisal

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