Antimicrobial photodynamic therapy for the treatment of teeth with apical periodontitis: a histopathological evaluation

Journal of Endodontics
Lea Assed Bezerra SilvaRaquel Assed Bezerra Silva

Abstract

This study evaluated the in vivo response of apical and periapical tissues of dogs' teeth with apical periodontitis after one-session endodontic treatment with and without antimicrobial photodynamic therapy (aPDT). Sixty root canals with experimentally induced apical periodontitis were instrumented and assigned to 4 groups receiving aPDT and root canal filling (RCF) or not: group aPDT+/RCF+ (n = 20): aPDT (photosensitizer phenothiazine chloride at 10 mg/mL for 3 minutes and diode laser [λ = 660 nm, 60 mW/cm(2)] for 1 minute) and RCF in the same session; group aPDT+/RCF- (n = 10); group aPDT-/RCF+ (n = 20), and group aPDT-/RCF- (n = 10). Teeth were restored, and the animals were killed after 90 days. Sections from the maxillas and mandibles were stained with hematoxylin-eosin and Mallory trichrome and examined under light microscopy. Descriptive (ie, newly formed apical mineralized tissue, periapical inflammatory infiltrate, apical periodontal ligament thickness, and mineralized tissue resorption) and quantitative (ie, periapical lesion size and number of inflammatory cells) microscopic analysis was performed. Quantitative data were analyzed by the Kruskal-Wallis and Dunn tests (α = .05). In the aPDT-treated groups, the periapic...Continue Reading

References

Aug 13, 1998·The Journal of Antimicrobial Chemotherapy·M Wainwright
Apr 20, 2001·International Endodontic Journal·R J De MoorG E Martens
Mar 27, 2003·International Endodontic Journal·N N DugasS Friedman
May 25, 2004·Antimicrobial Agents and Chemotherapy·Faten GadMichael R Hamblin
Mar 29, 2005·Antimicrobial Agents and Chemotherapy·T MaischC Abels
Jun 9, 2005·Lasers in Medical Science·Saskia A G LambrechtsJacob B Dankert
Feb 4, 2006·International Endodontic Journal·L-L KirkevangA Wenzel
Jul 27, 2007·Journal of Dental Research·K Konopka, T Goslinski
Jan 25, 2008·Journal of Endodontics·Aguinaldo Silva GarcezMartha Simões Ribeiro
Feb 5, 2008·Dental Materials : Official Publication of the Academy of Dental Materials·Serge BouillaguetJacques Schrenzel
May 20, 2008·Photomedicine and Laser Surgery·Michelle Bernardes FonsecaAna Lucia Franco Ricardo
May 24, 2008·Journal of Endodontics·Jacob Lee FimpleNikolaos S Soukos
Jun 18, 2009·Lasers in Medical Science·Valdir Gouveia GarciaLetícia Helena Theodoro
Mar 12, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Victoria EngelhardtKristjan Plaetzer
Oct 22, 2010·Photomedicine and Laser Surgery·Felipe Fornias SperandioSuzana C Orsini Machado de Sousa
Dec 8, 2010·Periodontology 2000·Nikolaos S Soukos, J Max Goodson
Jan 18, 2011·Journal of Endodontics·Raymond NgNikolaos S Soukos
Mar 18, 2011·Lasers in Surgery and Medicine·Stefan KranzBernd W Sigusch
Nov 29, 2011·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·José F Siqueira, Isabela N Rôças

❮ Previous
Next ❯

Citations

Oct 10, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Sigurd HafnerAndreas Wieser
Jan 23, 2016·Photodiagnosis and Photodynamic Therapy·João Eduardo Gomes-FilhoSandra Helena Penha de Oliveira
Feb 26, 2014·Journal of Endodontics·Florence BulitSerge Bouillaguet
May 19, 2012·Journal of Endodontics·Raquel Assed Bezerra da SilvaLea Assed Bezerra Silva
Jul 18, 2015·Photodiagnosis and Photodynamic Therapy·Fahim VohraFawad Javed
Jun 24, 2015·International Endodontic Journal·M C BorsattoL A Bezerra da Silva
Oct 24, 2014·Clinical Oral Investigations·Nestor CohencaPaulo Nelson-Filho
Feb 27, 2015·Photomedicine and Laser Surgery·Alessandra Cesar TrindadeJoão Batista Blessmann Weber
Jan 21, 2014·International Journal of Biological Macromolecules·Mohammad Reza Saboktakin, Roya Mahdavi Tabatabaee
Jun 15, 2016·Photodiagnosis and Photodynamic Therapy·Ramon Targino FirminoDaliana Queiroga de Castro Gomes
Nov 7, 2016·Photodiagnosis and Photodynamic Therapy·Charis BeltesChrissanthy Papadopoulou
Jul 23, 2015·Brazilian Dental Journal·Fernanda Ullmann LópezFabiana Vieira Vier-Pelisser
Jun 27, 2017·Journal of Photochemistry and Photobiology. B, Biology·Hui LiangQingyong Li
Jun 25, 2017·Lasers in Medical Science·Palloma Porto AlmeidaRobson Amaro Augusto da Silva
Nov 9, 2017·Clinical Oral Investigations·Rachel Garcia de Miranda, Ana Paula Vieira Colombo
Dec 12, 2017·Nanophotonics·Nasim KashefMichael R Hamblin
Dec 7, 2017·Journal of Applied Oral Science : Revista FOB·Carolina Maschietto PucinelliPaulo Nelson
May 12, 2018·Critical Reviews in Microbiology·Fabian CieplikTim Maisch
Sep 28, 2012·Clinical Oral Investigations·Hare GursoySelçuk Yilmaz
Oct 3, 2019·Brazilian Oral Research·Lea Assed Bezerra da SilvaRaquel Assed Bezerra da Silva
Dec 8, 2015·Clinical Oral Investigations·Tanja BochOlga Polydorou
Jun 14, 2017·Scientific Reports·Naomichi YonedaMikako Hayashi
May 12, 2017·Journal of Lasers in Medical Sciences·Mohammad AsnaashariPayam Paymanpour
Dec 15, 2018·International Endodontic Journal·G PlotinoM Mercade
May 26, 2017·Clinical Oral Investigations·David Jonathan Rodrigues GusmanJuliano Milanezi de Almeida
Nov 6, 2020·Lasers in Medical Science·Ana Carolina Fernandes CoutoArthur Belém Novaes Júnior

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.