Antimicrobial potentiality of actinobacteria isolated from two microbiologically unexplored forest ecosystems of Northeast India

BMC Microbiology
Ranjita DasDebajit Thakur

Abstract

Actinobacteria are often known to be great producers of antibiotics. The rapid increase in the global burden of antibiotic-resistance with the concurrent decline in the discovery of new antimicrobial molecules necessitates the search for novel and effective antimicrobial metabolites from unexplored ecological niches. The present study investigated the antimicrobial producing actinobacterial strains isolated from the soils of two microbiologically unexplored forest ecosystems, viz. Nameri National Park (NNP) and Panidehing Wildlife Sanctuary (PWS), located in the Eastern Himalayan Biodiversity hotspot region. A total of 172 putative isolates of actinobacteria were isolated, of which 24 isolates showed strong antimicrobial bioactivity. Evaluation of the ethyl acetate extracts of culture supernatants against test microbial strains revealed that isolates PWS22, PWS41, PWS12, PWS52, PWS11, NNPR15, NNPR38, and NNPR69 were the potent producers of antimicrobial metabolites. The antimicrobial isolates dominantly belonged to Streptomyces, followed by Nocardia and Streptosporangium. Some of these isolates could be putative novel taxa. Analysis of the antimicrobial biosynthetic genes (type II polyketide synthase and nonribosomal peptide sy...Continue Reading

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Citations

Dec 2, 2020·International Journal of Environmental Research and Public Health·Mohamed E HamidMartin R P Joseph
Feb 3, 2021·Microbiological Research·Polpass Arul JoseBhavanath Jha
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhanna Mohammed Al-ShaibaniHesham Ali El Enshasy

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Datasets Mentioned

BETA
KX255003
KX761862
KX575648
KX592593

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

ChemDraw Ultra
Sequence Scanner
MEGA6
ORF Finder
nucleotide BLAST
DECIPHER
BLAST
BLASTP
megablast

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