Antimicrobial practice. Development of guidelines for gentamicin dosing

The Journal of Antimicrobial Chemotherapy
A H ThomsonD Jodrell

Abstract

The performance of dosage guidelines for starting gentamicin therapy was evaluated prospectively in 50 patients with suspected or proven Gram-negative septicaemia and the results were compared with results from similar group of 50 patients for whom the guidelines were not followed. Peak concentrations were significantly higher when the guidelines were followed (7.2 (+/- 1.9) mg/L vs 5.7 (+/- 1.8) mg/L) but there was no difference in trough concentrations. Fifty-eight per cent of patients had both peak and trough concentrations within the target range (peak > 5 mg/L, trough < 2 mg/L) when doses were decided empirically; this increased to 96% when the guidelines were followed. However, use of the guidelines achieved peaks of > 7 mg/L in only 56% of patients. A revised protocol with higher doses given less frequently was therefore developed and a prospective assessment of its performance indicated that satisfactory concentrations were obtained in 96% of patients.

Citations

May 29, 2004·International Journal of Antimicrobial Agents·Dawei XuanCharles H Nightingale
Aug 5, 2000·International Journal of Antimicrobial Agents·D XuanC H Nightingale
Nov 13, 2010·Indian Journal of Nephrology·S Nayak-Rao
Aug 26, 2014·Drug Design, Development and Therapy·Jieon LeeHoward Lee
Aug 8, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Matthew S StankowiczDaniel L Brown
Jun 12, 1999·Therapeutic Drug Monitoring·D CampbellB Stack
Oct 9, 1998·British Journal of Clinical Pharmacology·M C RosarioH L Elliott

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