Antimicrobial properties and cytotoxicity of an antimicrobial monomer for application in prosthodontics

Journal of Prosthodontics : Official Journal of the American College of Prosthodontists
Rômulo Rocha RegisRaphael Freitas de Souza

Abstract

This study aimed to investigate the antimicrobial properties and cytotoxicity of the monomer methacryloyloxyundecylpyridinium bromide (MUPB), an antiseptic agent capable of copolymerizing with denture base acrylic resins. The antimicrobial activity of MUPB was tested against the species Candida albicans, Candida dubliniensis, Candida glabrata, Lactobacillus casei, Staphylococcus aureus, and Streptococcus mutans. The minimum inhibitory and fungicidal/bactericidal concentrations (MIC, MFC/MBC) of MUPB were determined by serial dilutions in comparison with cetylpyridinium chloride (CPC). The cytotoxic effects of MUPB at concentrations ranging from 0.01 to 1 g/L were assessed by MTT test on L929 cells and compared with methyl methacrylate (MMA). The antimicrobial activity of copolymerized MUPB was tested by means of acrylic resin specimens containing three concentrations of the monomer (0, 0.3, 0.6% w/w). Activity was quantified by means of a disc diffusion test and a quantification of adhered planktonic cells. Statistical analysis employed the Mann-Whitney test for MIC and MFC/MBC, and ANOVA for the microbial adherence test (α = 0.05). MUBP presented lower MIC values when compared with CPC, although differences were significant fo...Continue Reading

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Citations

Oct 22, 2013·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Indumathi SivakumarBindu Kamaraj
Sep 18, 2014·Brazilian Oral Research·Valdirene Alves dos SantosMaria Aparecida Borsatti
Dec 4, 2014·Journal of Applied Oral Science : Revista FOB·Denise Tornavoi de CastroAndréa Cândido dos Reis
Feb 14, 2013·The Journal of Contemporary Dental Practice·Nishna Pradeep, A V Sreekumar
May 7, 2021·International Journal of Nanomedicine·Qiao-Jun ZhangDa-Li Zheng
May 18, 2021·The Japanese Dental Science Review·Francisca Jennifer Duarte de OliveiraDiana Ferreira Gadelha de Araújo
Aug 18, 2020·The Journal of Prosthetic Dentistry·Steve AnRobert M Love

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