Antimicrobial Properties and Cytotoxicity of Sulfated (1,3)-β-D-Glucan from the Mycelium of the Mushroom Ganoderma lucidum.

Journal of Microbiology and Biotechnology
Wan Abd Al Qadr Imad Wan-MohtarBrian McNeil

Abstract

Ganoderma lucidum BCCM 31549 has a long established role for its therapeutic activities. In this context, much interest has focused on the possible functions of the (1,3)-β-D-glucan (G) produced by these cultures in a stirred-tank bioreactor and extracted from their underutilized mycelium. In the existing study, we report on the systematic production of G, and its sulfated derivative (GS). The aim of this study was to investigate G and its GS from G. lucidum in terms of their antibacterial properties and cytotoxicity spectrum against human prostate cells (PN2TA) and human caucasian histiocytic lymphoma cells (U937). (1)H NMR for both G and GS compounds showed β-glycosidic linkages and structural similarities when compared with two standards (laminarin and fucoidan). The existence of characteristic absorptions at 1,170 and 867 cm(-1) in the FTIR (Fourier Transform Infrared Spectroscopy) for GS demonstrated the successful sulfation of G. Only GS exhibited antimicrobial activity against a varied range of test bacteria of relevance to foodstuffs and human health. Moreover, both G and GS did not show any cytotoxic effects on PN2TA cells, thus helping demonstrate the safety of these polymers. Moreover, GS showed 40% antiproliferation...Continue Reading

Citations

Aug 5, 2017·Environmental Science and Pollution Research International·Soumya ChatterjeeDharmendra K Gupta
Feb 28, 2017·Food Science and Biotechnology·Wan Abd Al Qadr Imad Wan-MohtarSarina Abdul Halim Lim
Aug 11, 2020·Engineering in Life Sciences·Nadja RadchenkovaMargarita S Kambourova
Feb 21, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Débora Cássia Vieira GomesAna Amélia de Carvalho Melo Cavalcante
Jun 5, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Damini KothariSoo-Ki Kim

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