Antimicrobial properties of electrically formed elastomeric polyurethane-copper oxide nanocomposites for medical and dental applications

Methods in Enzymology
Z AhmadRobert P Allaker

Abstract

With the rapidly advancing field of nanotechnology having an impact in several areas interfacing life and physical sciences, the potential applications of nanoparticles as antimicrobial agents have been realized and offer great opportunities in addressing several viral and bacterial outbreak issues. Polyurethanes (PUs) are a diverse class of polymeric materials which also have applications in several areas of biomedical science ranging from blood contact devices to implantable dental technologies. In this report, copper oxide (CuO) nanoparticles (mean size ∼50 nm) are embedded into a PU matrix via two electrical fabrication processes. To elucidate the antimicrobial activity, a range of different loading compositions of CuO within the PU matrix (0%, 1%, 5%, and 10% w/w) are electrospun to form thin porous films (thickness < 10 μm). After washing, the films are tested for their antimicrobial properties against methicillin-resistant Staphylococcus aureus (MRSA). Significant reduction of populations was demonstrated with 10% w/w CuO over a 4-h period. This approach demonstrates the potential of generating tailored antimicrobial structures for a host of applications, such as designer filters, patterned coatings, breathable fabrics, ...Continue Reading

Citations

Oct 22, 2014·Applied Microbiology and Biotechnology·Idalina GonçalvesArtur Cavaco-Paulo
Nov 4, 2016·Neurochemical Research·Arundhati JoshiRalf Dringen
Aug 20, 2019·Pharmaceutical Development and Technology·Solmaz Maleki DizajAzin Jahangiri
Aug 2, 2020·Journal of Biochemical and Molecular Toxicology·Shereen A ElkhateebOmaima I Abdel Hamid
Aug 14, 2015·Neurochemical Research·Felix Bulcke, Ralf Dringen
Feb 4, 2021·Pharmaceutical Research·Muhammad Sohail ArshadZeeshan Ahmad
Dec 24, 2020·Critical Reviews in Food Science and Nutrition·Saeed AhmedYaowen Liu

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