Antimicrobial properties of platelet-rich preparations. A systematic review of the current pre-clinical evidence

Platelets
Massimo Del FabbroRoberto L Weinstein

Abstract

In recent years autologous platelet concentrates (APCs) have become popular in several medicine fields, representing a valuable adjunct to regenerative surgical procedures. Beneficial effects in the control of postsurgical discomfort and infection have also been frequently reported, suggesting that APC may possess anti-inflammatory and antimicrobial properties. The aim of the present review was to summarize the current evidence regarding the antimicrobial effects of platelet concentrates, investigated by in vitro and animal studies. This review was conducted following a systematic approach. An electronic search was performed on MEDLINE, EMBASE and Scopus databases using appropriate search terms, without language or time restrictions. Preclinical studies assessing the antimicrobial activity of APC were included and divided according to the experimental design. Twenty in vitro studies and four animal studies, investigating APC effects on a broad range of microorganisms, were included. In in vitro studies APC reduced the growth of microorganisms during the first hours of incubation, while they could not completely break down the microbial load. In fact, over time a recovery of bacterial growth was always observed, suggesting that ...Continue Reading

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Citations

Jun 24, 2017·Platelets·Sabrina MarcazzanMassimo Del Fabbro
Mar 15, 2018·Platelets·Roshan Noor MohamedYousef Al-Thomali
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Feb 9, 2017·Oral and Maxillofacial Surgery·Silvio TaschieriMassimo Del Fabbro
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