Antimicrobial prophylaxis for external ventricular drains in pediatric neurosurgical patients

Paediatric Drugs
Amanda P IfeachorElizabeth A Sinclair

Abstract

Our goal was to describe the use of antibiotics for surgical prophylaxis of external ventricular drains (EVDs) in a pediatric neurosurgical population and determine the incidence of EVD-related infections among different antimicrobial prophylaxis strategies. This retrospective chart review included patients up to 18 years old who underwent EVD insertion at either of two tertiary care academic hospitals in the same health system between August 1, 2008, and July 31, 2012. Patients were included if they received at least one dose of antibiotics before EVD insertion. Patients who received only perioperative antibiotics were compared with those who also received antibiotics after this period. The primary endpoint was incidence of EVD-related infection. Descriptive statistics were used to summarize baseline characteristics and compare antibiotic regimens between groups. Pearson's chi square and Mann Whitney U tests compared nonparametric data. A total of 182 EVD insertions were documented, and 88 included in the study. Of these 88, 27 were associated only with perioperative doses of antibiotics, and 61 with prolonged antibiotic use. Baseline characteristics and antibiotic choices were similar between the groups. At least 55 (63%) cat...Continue Reading

References

Aug 1, 1972·Journal of Neurosurgery·A R Wyler, W A Kelly
Mar 31, 2005·American Journal of Infection Control·Yaseen ArabiMaha A Almuneef
Nov 1, 2006·Current Neurology and Neuroscience Reports·Rafael Ortiz, Kiwon Lee
Jun 4, 2008·Journal of Neurosurgery. Pediatrics·Regina EymannMichael Kiefer
Nov 8, 2012·Joint Commission Journal on Quality and Patient Safety·Maryam RahmanWilliam A Friedman
Jan 19, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America

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Citations

Apr 13, 2018·International Angiology : a Journal of the International Union of Angiology·Trung PhanVinod Bansal
Mar 23, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jeffrey S RaskinSandi Lam
Jun 18, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Friederike Knerlich-Lukoschus, Martina Messing-Jünger

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