Antimicrobial Prophylaxis for Patients Undergoing Cardiac Surgery: Intraoperative Cefazolin Concentrations and Sternal Wound Infections

Antimicrobial Agents and Chemotherapy
Sheryl A ZelenitskyRobert E Ariano

Abstract

This study characterizes the pharmacodynamics of antimicrobial prophylaxis and sternal wound infections following cardiac surgery. Duration of surgery and cefazolin plasma concentration during wound closure were independently associated with surgical site infection at 30 days. Furthermore, a duration of surgery of >346 min and a total cefazolin closure concentration of <104 mg/liter were significant thresholds for an increased risk of infection. This study provides new data that informs dosing strategies for effective antimicrobial prophylaxis (AP) in patients undergoing cardiac surgery with cardiopulmonary bypass.

References

Aug 29, 2000·Xenotransplantation·UNKNOWN Xenotransplantation Subcommittee (Subcmomittee of the Biological Response Modifiers Advisory Commitee). Fod and Drug Adminis
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·Sheryl A ZelenitskyRichard E Silverman
May 21, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T KosakaN Fujita
Nov 28, 2012·International Journal of Antimicrobial Agents·P Moine, D N Fish
Jan 19, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America
Mar 21, 2015·International Journal of Clinical Pharmacy·Marieke AalbersAlexander J Spanjersberg
Jun 25, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew J LabrecheHien M Nguyen
Jul 13, 2016·The Journal of Antimicrobial Chemotherapy·S A ZelenitskyG G Zhanel
Feb 1, 2017·The Journal of Hospital Infection·D J Leaper, C E Edmiston
Mar 4, 2017·International Journal of Antimicrobial Agents·Fathima ParukJason A Roberts
Apr 4, 2017·The Journal of Antimicrobial Chemotherapy·Robert E ArianoLavern M Vercaigne
Apr 15, 2017·Intensive Care Medicine·T TängdénUNKNOWN Infection Section for the European Society of Intensive Care Medicine, the Pharmacokinetics and Pharmacodynamics Study Group
May 4, 2017·JAMA Surgery·Sandra I Berríos-TorresUNKNOWN Healthcare Infection Control Practices Advisory Committee
Dec 14, 2017·The Journal of Antimicrobial Chemotherapy·Divna CalicSheryl A Zelenitsky

❮ Previous
Next ❯

Citations

Nov 10, 2018·Pharmacology Research & Perspectives·Mizuho AsadaMasato Yasuhara
Jul 17, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jessica Suna, Nelson Alphonso
Jul 17, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Radoslaw JaworskiAndrzej Kansy

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Related Papers

Journal of Cardiothoracic and Vascular Anesthesia
R S AdsumelliG L Hicks
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Ulrich O von Oppell, Kandadai S Rammohan
© 2022 Meta ULC. All rights reserved