Antimicrobial resistance among Gram-negative bacilli causing infections in intensive care unit patients in the United States between 1993 and 2004

Journal of Clinical Microbiology
Shawn R LockhartGary V Doern

Abstract

During the 12-year period from 1993 to 2004, antimicrobial susceptibility profiles of 74,394 gram-negative bacillus isolates recovered from intensive care unit (ICU) patients in United States hospitals were determined by participating hospitals and collected in a central location. MICs for 12 different agents were determined using a standardized broth microdilution method. The 11 organisms most frequently isolated were Pseudomonas aeruginosa (22.2%), Escherichia coli (18.8%), Klebsiella pneumoniae (14.2%), Enterobacter cloacae (9.1%), Acinetobacter spp. (6.2%), Serratia marcescens (5.5%), Enterobacter aerogenes (4.4%), Stenotrophomonas maltophilia (4.3%), Proteus mirabilis (4.0%), Klebsiella oxytoca (2.7%), and Citrobacter freundii (2.0%). Specimen sources included the lower respiratory tract (52.1%), urine (17.3%), and blood (14.2%). Rates of resistance to many of the antibiotics tested remained stable during the 12-year study period. Carbapenems were the most active drugs tested against most of the bacterial species. E. coli and P. mirabilis remained susceptible to most of the drugs tested. Mean rates of resistance to 9 of the 12 drugs tested increased with Acinetobacter spp. Rates of resistance to ciprofloxacin increased ove...Continue Reading

References

Oct 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G S ItokazuRobert A Weinstein
Aug 10, 2000·The Journal of Antimicrobial Chemotherapy·W GoettschA J de Neeling
Oct 6, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H WisplinghoffH Seifert
Mar 29, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·C UrbanJ J Rahal
Apr 26, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ana Cristina GalesR Ramphal
Sep 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E LautenbachN O Fishman
Jan 17, 2002·Pharmacotherapy·Kerry M EmpeyMartin E Evans
Jul 4, 2002·Emerging Infectious Diseases·Scott K FridkinIntensive Care Antimicrobial Resistance Epidemiology Project Hospitals
Jan 25, 2003·Surgical Infections·Joseph A PaladinoJerome J Schentag
Feb 18, 2003·JAMA : the Journal of the American Medical Association·Melinda M NeuhauserJohn P Quinn
Apr 12, 2003·Critical Care Medicine·Daniel P RaymondRobert G Sawyer
Aug 28, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Ian R FriedlandGail L Woods
Nov 3, 2004·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Erika M C D'Agata
Feb 17, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·W V KernR Marre
May 24, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Aurora E Pop-Vicas, Erika M C D'Agata
Aug 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R P GaynesNational Nosocomial Infections Surveillance System
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara E Cosgrove
Dec 20, 2005·Diagnostic Microbiology and Infectious Disease·Serhat Unal, Jose Angel Garcia-Rodriguez
Aug 9, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L Paterson
Sep 5, 2006·Diagnostic Microbiology and Infectious Disease·Paul R Rhomberg, Ronald N Jones

Citations

Oct 19, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Stephen P HawserP Hawkey
Jun 17, 2009·Nature Reviews. Microbiology·Robert P RyanJ Maxwell Dow
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Evan S SnitkinJulie A Segre
Aug 30, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R Monina KlevensNational Nosocomial Infections Surveillance System
Mar 18, 2008·The Journal of Antimicrobial Chemotherapy·Jonas MarschallDavid K Warren
May 14, 2009·The Journal of Antimicrobial Chemotherapy·M N Al-HasanL M Baddour
Sep 24, 2010·The Journal of Antimicrobial Chemotherapy·Sidharth ChopraAmit K Galande
Apr 23, 2013·The Journal of Antimicrobial Chemotherapy·George G ZhanelCanadian Antimicrobial Resistance Alliance
Nov 23, 2010·Journal of Tropical Pediatrics·S M BrindhaNeelam Taneja
May 2, 2008·Critical Care Medicine·Bryan Dotson, Martin J Ohlinger
Jul 29, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·John BadgerVicki Nienaber
Jun 17, 2011·International Journal of Clinical Practice·J A Bosso, R H Drew
Aug 24, 2012·Science Translational Medicine·Evan S SnitkinJulia A Segre
Jun 17, 2009·Antimicrobial Agents and Chemotherapy·Mark D AdamsRobert A Bonomo
Dec 24, 2009·Antimicrobial Agents and Chemotherapy·M Indriati HoodEric P Skaar
Mar 3, 2010·Antimicrobial Agents and Chemotherapy·Yu-Chi LinShu-Ying Li
Jan 16, 2013·Antimicrobial Agents and Chemotherapy·Laurence Armand-LefèvreAntoine Andremont
Oct 7, 2011·Clinical Microbiology Reviews·Steven D Mahlen
Jan 11, 2012·Clinical Microbiology Reviews·Joanna S Brooke
Nov 23, 2011·Infection and Immunity·Leticia V BentancorTomás Maira-Litrán
Oct 22, 2008·Journal of Bacteriology·Mark D AdamsSteven R Gill
Jan 15, 2013·Journal of Bacteriology·Matthew D NortonVeronica G Godoy
Sep 6, 2011·Journal of Bacteriology·Sarah L MurdochSarah J Coulthurst
Mar 28, 2009·BMC Research Notes·Stephen E MshanaEligius F Lyamuya
Dec 9, 2010·International Journal of Environmental Research and Public Health·João P S Cabral
Jan 25, 2014·International Journal of Critical Illness and Injury Science·Mahendra K PatelCb Tripathi
Jul 17, 2014·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Abbas BahadorFarhad B Hashemi
Sep 23, 2014·International Journal of Antimicrobial Agents·Daichi KazamoriAkira Yazaki
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lisa L Maragakis, Trish M Perl
Feb 22, 2012·Scandinavian Journal of Infectious Diseases·Hye Won KimYoung Goo Song
May 11, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chi-Yu ChenChun-Yu Lin
Jun 18, 2011·The Medical Clinics of North America·Maureen K Bolon
Feb 16, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Hai-Fei YangJia-Bin Li
Apr 16, 2011·American Journal of Infection Control·Graham M SnyderErika M C D'Agata
Nov 16, 2010·International Journal of Antimicrobial Agents·S Christian CheathamMichael B Kays
Jan 6, 2010·International Journal of Antimicrobial Agents·Hui WangXinhong Huang
Nov 17, 2009·Infectious Disease Clinics of North America·Maureen K Bolon
Jan 16, 2016·The Journal of Antimicrobial Chemotherapy·María Pérez-VázquezRobert A Kingsley
Jan 13, 2011·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Christopher A Ohl, Vera P Luther
Oct 17, 2015·Genome Announcements·Jingwen GuanGabriel F Kuty Everett
Feb 20, 2015·Applied Microbiology and Biotechnology·Jaejoon Jung, Woojun Park
Aug 7, 2013·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Marya D Zilberberg, Andrew F Shorr
Dec 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Verica AleksicPetar Knezevic
Feb 24, 2012·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Jing SunJia-Bin Li
Nov 25, 2011·International Journal of Antimicrobial Agents·Marie Kempf, Jean-Marc Rolain
Dec 3, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Masayoshi TojoNorio Ohmagari
Jan 4, 2012·FEMS Immunology and Medical Microbiology·Anna C JacobsPaul M Dunman
Jan 8, 2015·Advances in Wound Care·Geoffrey D HanniganSamir Mehta
Jun 4, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M N Al-HasanL M Baddour
Jul 5, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M L MezzatestaS Stefani
Oct 25, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Alicia I HidronParticipating National Healthcare Safety Network Facilities
Feb 14, 2015·PLoS Pathogens·Edward Geisinger, Ralph R Isberg
Aug 30, 2008·Journal of Critical Care·Arthur R H van ZantenArmand R J Girbes
Nov 18, 2016·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Shirin BiglariBruno Silvester Lopes
Oct 7, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jonas MarschallDavid K Warren
Dec 25, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Marc S HoffmannRamanan Laxminarayan
Jul 1, 2008·Expert Review of Anti-infective Therapy·Thomas D Gootz, Andrea Marra
Nov 16, 2017·Annals of Clinical Microbiology and Antimicrobials·Nguyen Si-TuanNguyen Thuy Huong
Feb 26, 2015·Antimicrobial Agents and Chemotherapy·Dana R BowersVincent H Tam
Dec 9, 2015·Infection and Immunity·Corin V WhiteMichael A Herman
Aug 13, 2014·Infection and Immunity·Zhimin FengAaron Weinberg
Dec 30, 2015·Antimicrobial Agents and Chemotherapy·Lisa Yun SongJeffrey H Miller
Jan 15, 2015·Antimicrobial Agents and Chemotherapy·Tricia A Van LaarKai P Leung
May 9, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·David S Burgess, Robert P Rapp
Nov 2, 2014·The European Respiratory Journal·Jordi RieraVall d’Hebron Lung Transplant Study Group
Mar 11, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·William Gustavo LimaMagna Cristina Paiva
Nov 30, 2018·The Pediatric Infectious Disease Journal·Lukas WisgrillAngelika Berger
Mar 3, 2010·Expert Review of Anti-infective Therapy·Nicola PetrosilloFabrizio Taglietti
Apr 21, 2011·Expert Review of Anti-infective Therapy·Iain J AbbottLeon J Worth
Jun 13, 2014·The Journal of Veterinary Medical Science·Bita BakhshiSaeed Sepehri-Seresht
Nov 26, 2010·Médecine sciences : M/S·François Barbier, Michel Wolff
Jun 30, 2010·The Annals of Otology, Rhinology, and Laryngology·Jong Hwan WangYong Ju Jang
Jul 4, 2012·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Kayla BarettaMichael N G James
Jul 28, 2017·Therapeutic Advances in Infectious Disease·Rajiv SontiDaniel B Jamieson
Aug 29, 2018·Antimicrobial Agents and Chemotherapy·Richard E NelsonMatthew H Samore
Jun 17, 2011·Current Opinion in Critical Care·Elchanan FriedCharles Sprung
Feb 9, 2019·Antimicrobial Resistance and Infection Control·Han Sang LeeKon Chu
Dec 1, 2018·The Journal of Antimicrobial Chemotherapy·Andrew J DenisuikGeorge G Zhanel
Aug 9, 2017·Microbial Genomics·Robert J Goldstone, David G E Smith
May 11, 2019·Microbiology Resource Announcements·Brian T KoehlerMei Liu
Oct 13, 2020·Journal of Intensive Care Medicine·Rodney A GabrielUlrich H Schmidt
Dec 15, 2020·Journal of Global Antimicrobial Resistance·Ghada El-Saeed Mashaly, Mervat El-Sayed Mashaly
Sep 12, 2020·Journal of Food Protection·Behailu B EsheteaBroderick Eribo
Feb 7, 2018·Indian Journal of Medical Microbiology·Lipika SinghalVikas Gautam
Feb 25, 2021·Foodborne Pathogens and Disease·Mohamed M A ZeinhomHarold Corke
Jan 8, 2021·Journal of Food Protection·Behailu B EsheteaBroderick Eribo
Oct 21, 2011·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Deep GagnejaUma Chaudhary

Related Concepts

Related Feeds

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.