Antimicrobial Resistance Analysis of Clinical Escherichia coli Isolates in Neonatal Ward.

Frontiers in Pediatrics
Dan WuYajuan Wang

Abstract

Background:Escherichia coli (E. coli) column for one of the most common pathogens causing neonatal infections. The emergence of antibiotic-resistant bacteria is a major cause of treatment failure in infected newborns. The purpose of this study was to describe antibiotic and multidrug resistance of E. coli strains isolated from neonates with infection throughout the years 2009-2011. Methods: The antimicrobial susceptibility testing of E. coli strains to selected antibiotics was assessed using the E-test technique on the Mueller-Hinton agar. The antimicrobial tests included ceftazidime, cefuroxime, cefatriaxone, amoxicillin, amoxicillin-clavulanic acid, cefoperazone- sulbactam, meropenem, gentamicin, ciprofloxacin, and sulfonamides. Results: A total of 100 E. coli strains were isolated from sputum (n = 78), blood (n = 10), cerebrospinal fluid (n = 5), and umbilical discharge (n = 7) samples of hospitalized neonates at the Beijing Children's Hospital. The highest rate of E. coli resistance was found in amoxicillin (85%), followed by cefuroxime (65%), and cefatriaxone (60%), respectively. A total of 6 and 5% of all isolates were only resistant to amoxicillin/clavulanic acid and cefoperazone -sulbactam. The rates of resistance to ce...Continue Reading

References

Dec 10, 2009·Antimicrobial Agents and Chemotherapy·Karen Bush, George A Jacoby
May 15, 2012·Lancet·Li LiuUNKNOWN Child Health Epidemiology Reference Group of WHO and UNICEF
Jul 31, 2013·Antimicrobial Agents and Chemotherapy·David M ShlaesBrad Spellberg
Apr 30, 2015·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Aneta Nitsch-OsuchKazimierz Wardyn
Jun 13, 2015·The Pediatric Infectious Disease Journal·Stephen P BerginUNKNOWN Antibacterial Resistance Leadership Group
Aug 5, 2017·European Journal of Pediatrics·Natalia Mendoza-PalomarPere Soler-Palacin
Oct 11, 2017·Annals of Emergency Medicine·Elizabeth C PowellUNKNOWN Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN)
Apr 25, 2018·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jing-Yang LiJing Lin
Jun 14, 2018·Frontiers in Immunology·Danny HarbesonTobias R Kollmann

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