Antimicrobial resistance and epidemiological study of Haemophilus influenzae strains isolated in Portugal. The Multicentre Study Group

The Journal of Antimicrobial Chemotherapy
M P Bajanca-LavadoM V Vaz Pato

Abstract

In the course of a multicentric surveillance study, nine laboratories sent 375 isolates of Haemophilus influenzae to the Sector de Resistência aos Antibióticos (SRA) from the National Institute of Health in Lisbon, between 1 January and 31 December 1992. The majority of the H. influenzae isolates were from the respiratory tract (84.8%); only 5.1% were of invasive origin. Overall resistance for ampicillin was 11.7%, tetracycline 3.7%, and chloramphenicol 2.4%. All isolates tested were fully susceptible to cefotaxime, ceftriaxone, ciprofloxacin and rifampicin. Multiresistance was rare, occurring only in 2.4% of the isolates, although 50% of the ampicillin resistant strains had at least one additional resistance marker. Forty two isolates (11.2%) produced a TEM-1 type beta-lactamase, as shown by isoelectric focusing. beta-lactamase production was not detected in two of the ampicillin resistant strains. Fifteen of the 42 beta-lactamase producing strains (35.7%) contained detectable DNA plasmid: nine harboured large plasmids with an apparent molecular mass of 45 or 54 kb depending on their resistance phenotype and six harboured a small plasmid of 5 kb. In order to study transfer of resistance in both ampicillin and multiresistant st...Continue Reading

Citations

Jan 4, 2001·International Journal of Antimicrobial Agents·D Gür, S Unal
Apr 20, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·J Melo-CristinoUNKNOWN Portuguese Surveillance Group for the Study of Respiratory Pathogens
Feb 10, 2004·Journal of Clinical Microbiology·Paula BajancaUNKNOWN Multicenter Study Group
Oct 25, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M P Bajanca-LavadoUNKNOWN Portuguese Group for Study of Haemophilus influenzae invasive infection
Oct 24, 2000·Tropical Medicine & International Health : TM & IH·M LarssonT Falkenberg
Mar 31, 2006·Revista portuguesa de pneumologia·J Melo-CristinoUNKNOWN Grupo de Estudo Português de Bactérias Patogénicas Respiratórias
Apr 12, 2000·Journal of Paediatrics and Child Health·Y S LeeB W Lee

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