Antimicrobial resistance, biofilm formation and virulence reveal Actinobacillus pleuropneumoniae strains' pathogenicity complexity

Research in Veterinary Science
Monalessa F PereiraDenise Mara Soares Bazzolli

Abstract

Porcine pleuropneumonia is an important cause of lowered productivity and economic loss in the pig industry worldwide, associated primarily with Actinobacillus pleuropneumoniae infection. Its colonization and persistence within the upper respiratory tract of affected pigs depends upon interactions between a number of genetically controlled virulence factors, such as pore-forming repeats-in-toxin exoproteins, biofilm formation, and antimicrobial resistance. This study investigated correlations between biofilm-forming capacity, antimicrobial resistance, and virulence of A. pleuropneumoniae obtained from clinical outbreaks of disease, using a Galleria mellonella alternative infection model. Results suggest that virulence is diverse amongst the 21 strains of A. pleuropneumoniae examined and biofilm formation correlated with genetic control of antimicrobial resistance.

Citations

Mar 10, 2020·International Journal of Genomics·Isabelle Gonçalves de Oliveira PradoDenise Mara Soares Bazzolli
Jul 17, 2020·Antonie van Leeuwenhoek·J Fernando Montes GarcíaErasmo Negrete Abascal
Sep 25, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Monalessa Fábia Pereira, Ciro César Rossi
Sep 23, 2020·Pathogens and Disease·Monalessa Fábia PereiraDenise Mara Soares Bazzolli
Oct 24, 2020·Pathogens and Disease·Josicelli Souza CrispimDenise Mara Soares Bazzolli
Dec 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomas DoOndrej Zitka
Jun 7, 2019·International Journal of Biological Macromolecules·Pollyanna Michelle da SilvaThiago Henrique Napoleão

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