Oct 5, 2019

Antimicrobial resistance gene prevalence in a population of patients with advanced dementia is related to specific pathobionts

BioRxiv : the Preprint Server for Biology
Aislinn D. Rowan-NashPeter Belenky

Abstract

Background: The issue of antimicrobial resistance continues to grow worldwide, and long-term care facilities are significant reservoirs of antimicrobial-resistant organisms, in part due to high frequency of antimicrobial use. Patients with advanced dementia are particularly vulnerable to multidrug-resistant organism acquisition and antimicrobial overuse, which has negative consequences for the gut microbiome and can contribute to the selection and propagation of antimicrobial resistance genes. In this study, we longitudinally examined a group of advanced dementia patients treated with the fluoroquinolone antimicrobial levofloxacin, finding a correlation between abundance of pathogens and antimicrobial resistance genes, which we confirmed in a larger cohort of subjects with advanced dementia. Results: We observed significant inter- and intra-subject heterogeneity in the composition of the microbiota of the longitudinal levofloxacin cohort, suggesting temporal instability. Within this dataset, we did not find significant impacts of levofloxacin on the diversity, composition, function, or resistome of the gut microbiota of this population. However, we were able to link the antimicrobial resistance gene burden in a sample with the ...Continue Reading

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Mentioned in this Paper

Study
Genome
Genes
Administration Procedure
Resistance Process
Providencia stuartii
Species
Proteus mirabilis
Enterococcus faecalis
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