Antimicrobial resistance in clinical Escherichia coli isolated from companion animals in Australia

Veterinary Microbiology
Sugiyono SaputraSam Abraham

Abstract

Multidrug-resistant (MDR) Escherichia coli have become a major public health concern to both humans and animal health. While the frequency of antimicrobial resistance (AMR) in clinical E. coli is monitored regularly in human medicine, current frequency of AMR in companion animals remains unknown in Australia. In this study we conducted antimicrobial susceptibility testing (AST) and where possible, determined potential risk factors for MDR infection among 883 clinical Escherichia coli isolated from dogs (n=514), cats (n=341) and horses (n=28). AST was undertaken for 15 antimicrobial agents according to the Clinical Laboratory Standards Institute (CLSI) guidelines and interpreted using epidemiological cut-off values (ECOFFs) as well as CLSI veterinary and human clinical breakpoints. The AST revealed complete absence of resistance to carbapenems while resistance to amikacin was observed at a low level in isolates from dogs (1.6%) and cats (1.5%) compared to horses (10.7%). Among dog isolates, resistance to fluoroquinolones ranged from 9.1%-9.3% whereas among cat isolates, it ranged from 3.2%-5%. Among dog isolates, the proportion showing a 3rd generation cephalosporin (3GC) non-wild type phenotype was significantly higher (P<0.05)...Continue Reading

Citations

Jun 12, 2019·Journal of Veterinary Pharmacology and Therapeutics·Benjamin KimbleMerran Govendir
Aug 6, 2020·Environmental Microbiology Reports·Isabel CarvalhoPatrícia Poeta
Jun 27, 2019·Australian Veterinary Journal·S L Raidal
Feb 11, 2021·International Journal of Microbiology·Laura MarchettiNora Mestorino
Feb 21, 2021·Comparative Immunology, Microbiology and Infectious Diseases·Letícia MachadoÁlan Gomes Pöppl
Jan 26, 2022·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Annelize JonkerAlischa Henning

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