PMID: 9552714Jan 1, 1997Paper

Antimicrobial resistance in gonococci isolated from patients and from commercial sex workers in Harare, Zimbabwe

International Journal of Antimicrobial Agents
P R MasonD A Katzenstein

Abstract

The objective is to compare antibiotic resistance amongst gonococci isolated from different patient groups in Harare, Zimbabwe. Antimicrobial susceptibilities of Neisseria. gonorrhoeae were determined by disc sensitivity tests. The MICs for penicillin, kanamycin, ceftriaxone, norfloxacin and ciprofloxacin were determined using E-test strips. There were 147 isolates from symptomatic men, 47 isolates from symptomatic women, 29 isolates from asymptomatic women and 41 isolates from female commercial sex workers. A total of 119 (45%) isolates were PPNG and 23 (16%) non-PPNG isolates had a penicillin MIC > 0.64 mg/l. Over 90% of isolates were resistant to TMP/SMX and 16% were resistant to tetracycline. Resistance was uncommon against kanamycin (6%), erythromycin (2%) or ceftriaxone ( < 1%). For kanamycin, the MIC90 was 32 mg/l, for ceftriaxone the MIC90 was < 0.032 mg/l for non-PPNG and < 0.064 mg/l for PPNG. For norfloxacin and ciprofloxacin the MIC90 was < 0.064 mg/l for both PPNG and non-PPNG. Isolates from the commercial sex workers showed a significantly increased prevalence of PPNG, of penicillin-tolerant non-PPNG and of tetracycline resistance. Four of the 41 isolates from sex workers showed multiple resistance (to penicillin,...Continue Reading

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Citations

May 18, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·P Shears
Apr 23, 2004·Expert Opinion on Pharmacotherapy·Michael Dan
Sep 16, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Thomas RegnathRalf Ignatius
Jan 27, 2007·Diagnostic Microbiology and Infectious Disease·Amira ZairiKhaled Hani
Mar 26, 2002·Sexually Transmitted Diseases·Shunzhang YeHouhua Sun
Mar 22, 2019·Journal of Clinical Microbiology·Alexey KubanovDmitry Deryabin
Jun 8, 2000·Tropical Doctor·P Shears
Jan 16, 2021·Antibiotics·Willis GwenziAkebe Luther King Abia

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