Antimicrobial Resistance in Leptospira , Brucella , and Other Rarely Investigated Veterinary and Zoonotic Pathogens

Microbiology Spectrum
Darren J TrottBen Adler

Abstract

Leptospira, Brucella, and Borrelia are major agents of zoonotic disease, causing high morbidity and, in some cases, significant mortality in humans. For all three genera, prompt diagnosis and appropriate antimicrobial therapy are required to prevent the development of chronic, debilitating illness. Leptospira spp. are intrinsically resistant to several antimicrobial classes; however, there is little evidence in the literature for development of acquired resistance to antimicrobial agents used for clinical treatment of acute leptospirosis. For Brucella infections, there are numerous reports of relapses following therapy, but it is unclear whether this is due to sequestration within infected sites (e.g., bone) or the development of acquired resistance. Brucella have maintained their susceptibility to doxycycline and rifampicin, which in combination remain the most common treatments of brucellosis in humans. In vitro induced point mutations are described as imparting resistance to rifampicin (rpoB) and fluoroquinolones (gyrA). The clinical significance of these mutations is unclear. For Borrelia burgdorferi, although acquired resistance to some antimicrobial agents has been described, resistance due to bacterial persister cells su...Continue Reading

References

Jun 1, 1976·Australian Veterinary Journal·T H Norton, A D Thomas
Feb 1, 1990·The Journal of Antimicrobial Chemotherapy·M B al-Sibai, S M Qadri
Nov 1, 1986·The Journal of Antimicrobial Chemotherapy·Y M De Rautlin de la RoyB Becq-Giraudon
Oct 1, 1985·Antimicrobial Agents and Chemotherapy·J ArizaP Fernández-Viladrich
Aug 1, 1970·British Medical Journal·S LalR D Popham
May 1, 1994·Journal of Bacteriology·D S SamuelsC F Garon
Mar 7, 1998·Parasitology·N H OgdenS E Randolph
Mar 8, 2000·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K P HunfeldV Brade
Apr 13, 2000·The Journal of Infection·Z MemishM Y Khan
Sep 11, 2001·Journal of the American Veterinary Medical Association·D P AltC A Bolin
Jun 6, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S KocagözG Hasçelik
Oct 18, 2002·Antimicrobial Agents and Chemotherapy·Darya TerekhovaFelipe C Cabello
Jan 1, 2003·Veterinary Research Communications·A StefancíkováM Trávnicek
Apr 8, 2003·Journal of Chemotherapy·M AlmuneefH H Balkhy
Apr 30, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mohammed Al ShaalanSuleiman Alalola
Jul 3, 2003·The Journal of Antimicrobial Chemotherapy·Mark CasewellIan Phillips
Sep 1, 1955·The Journal of Infectious Diseases·S FAINE, W J KAIPAINEN
Oct 1, 1961·Canadian Journal of Microbiology·J G COUSINEAU, J A McKIEL
Apr 15, 2004·International Journal of Antimicrobial Agents·Nurcan BaykamBaşak Dokuzoguz
Sep 25, 2004·Antimicrobial Agents and Chemotherapy·Clinton K Murray, Duane R Hospenthal
Dec 8, 2004·Journal of Clinical Microbiology·Cinzia MarianelliRosanna Adone
Sep 29, 2005·Antimicrobial Agents and Chemotherapy·Kendal M GalbraithD Scott Samuels
Oct 13, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·T S DimitrovR Passadilla
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·Matthew E Falagas, Ioannis A Bliziotis
Jan 27, 2006·Antimicrobial Agents and Chemotherapy·Daniel CriswellD Scott Samuels
May 26, 2006·Antimicrobial Agents and Chemotherapy·James E MoonClinton K Murray
May 2, 2007·Antimicrobial Agents and Chemotherapy·Matthew E GriffithClinton K Murray
Oct 2, 2007·International Journal of Antimicrobial Agents·Charlene R JacksonFrank C Gherardini
Dec 29, 2007·PLoS Medicine·Javier ArizaUNKNOWN Institute of Continuing Medical Education of Ioannina
Jun 28, 2008·International Journal of Antimicrobial Agents·Aun TurkmaniYannis Tselentis
Oct 1, 2008·Veterinary Microbiology·Suphot WattanaphansakConnie J Gebhart

❮ Previous
Next ❯

Citations

Jan 1, 2020·Pathogens·Vladimir V BammMelanie K B Wills
Mar 20, 2019·The American Journal of Tropical Medicine and Hygiene·Jennifer BossMatthew T Robinson
Aug 6, 2020·Antibiotics·Fabrizio BertelloniFilippo Fratini
Jan 4, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Krishnan Baby Karpagam, Balasubramanian Ganesh
Mar 25, 2021·Microbial Pathogenesis·Jiuxi LiuYongguo Cao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brucellosis

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Brucellosis (ASM)

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.