Antimicrobial resistance in Mycobacterium abscessus complex isolated from patients with skin and soft tissue infections at a tertiary teaching hospital in Taiwan

The Journal of Antimicrobial Chemotherapy
Ming-Chun LeeTing-Shu Wu

Abstract

Mycobacterium abscessus complex (MABC) is the most common non-tuberculous mycobacterium that causes complicated skin and soft tissue infections (cSSTIs). The selection of antimycobacterial agents for successful treatment of such infections is a critical issue. To investigate the antimicrobial susceptibility patterns of MABC isolates from skin and soft tissue to a variety of antimycobacterial agents. Sixty-seven MABC isolates were collected and partial gene sequencing of secA1, rpoB and hsp65 was used to classify them into three subspecies: M. abscessus subsp. abscessus (MAB), M. abscessus subsp. massiliense (MMA) and M. abscessus subsp. bolletii (MBO). The MICs of 11 antimycobacterial agents for these 67 isolates were determined using a broth microdilution method and commercial Sensititre RAPMYCOI MIC plates, as recommended by CLSI. In total, 28 MAB, 38 MMA and 1 MBO were isolated from patients with cSSTIs at our hospital. Most MABC strains were resistant to ciprofloxacin, doxycycline, imipenem, linezolid, minocycline, moxifloxacin and trimethoprim/sulfamethoxazole. In addition, most MABC strains were intermediately susceptible or resistant to cefoxitin. Eighteen of the 28 MABs and 1 MBO isolate harboured the T28 polymorphism i...Continue Reading

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Citations

Nov 28, 2018·Antimicrobial Agents and Chemotherapy·Meiping YeHaiqing Chu
Jan 24, 2019·Antimicrobial Agents and Chemotherapy·Aristine ChengShan-Chwen Chang
Feb 12, 2020·Antimicrobial Agents and Chemotherapy·Clément RaynaudLaurent Kremer
Oct 16, 2018·Frontiers in Microbiology·Elizabeth Story-RollerGyanu Lamichhane
May 20, 2021·MBio·Mark R SullivanCharles L Dulberger
Dec 27, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jen-Yu HsuUn-In Wu

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