Antimicrobial resistance of Haemophilus influenzae isolated from the nasopharynx of Japanese children with acute otitis media

Acta Oto-laryngologica
Muneki HotomiNoboru Yamanaka

Abstract

A high prevalence of penicillin-binding protein gene-mutated (PGM) strains of Haemophilus influenzae should be taken into account when treating otitis media in children. To evaluate the prevalence of beta-lactamase-non-producing ampicillin-resistant strains of H. influenzae with mutations in the ftsI gene encoding penicillin-binding protein 3 (PBP3) among children with otitis media. A total of 644 nasopharyngeal isolates of H. influenzae were collected from pediatric acute otitis media patients with or without otitis media with effusion at the clinics of the Department of Otolaryngology-Head and Neck Surgery, Wakayama Medical University Hospital and 6 affiliated hospitals in Wakayama Prefecture between January 1999 and December 2003. MICs to ampicillin (AMP), cefdinir (CFD), cefaclor (CCL), cefpodoxime (CPD) and cefcapene (CFPN) were determined by a microbroth dilution method according to the recommendations of the National Committee for Clinical Laboratory Standards. Types of mutations in the PBP3 gene (ftsI) were evaluated by means of a polymerase chain reaction (PCR)-based genotyping method. The beta-lactamase gene (bla) was also identified by means of PCR. Beta-lactamase-producing (BLP) strains having the bla gene were iden...Continue Reading

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Citations

May 7, 2013·The Journal of Antimicrobial Chemotherapy·Elizabeth A WitherdenStephen G Tristram
Jan 21, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kozue KishiiKimiko Ubukata
Jun 25, 2008·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Noboru YamanakaDewan S Billal
Aug 19, 2007·Archivos de bronconeumología·Salvador Bello Dronda, Manuel Vilá Justribó

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