Antimicrobial resistance of Staphylococcus aureus isolated from skin infections

International Journal of Antimicrobial Agents
Setsuko Nishijima, Ichiro Kurokawa

Abstract

The antimicrobial susceptibility of 229 strains of Staphylococcus aureus isolated from various skin infections was determined against 22 antimicrobial agents by the agar dilution method. The clinical isolates were most sensitive to vancomycin, teicoplanin, mupirocin and fusidic acid. No strains were resistant to vancomycin or teicoplanin. Three strains were highly resistant (MIC > or =100 mg/l) to mupirocin and eight strains to fusidic acid. The MIC(50) of all antimicrobials, except for gentamicin, were below 3.13 mg/l. The incidence of resistance to penicillin, cephalosporins and clindamycin ranged from 20 to 30%. The occurrence of gentamicin, erythromycin and roxithromycin resistance was high at 55.2, 39.6 and 39.1%, respectively. Methicillin resistance occurred in 21.0% of strains. The incidence of organisms with MIC > or =3.13 mg/l to oxacillin was 24.3%. These results were comparable to the average rate of MRSA in Japanese dermatological specimens.

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Citations

Jan 23, 2013·Medical Molecular Morphology·Kenji FukutsujiTamotsu Harada
Jan 17, 2004·Journal of the American Academy of Dermatology·Philip R Cohen, Razelle Kurzrock
Aug 14, 2002·Journal of Applied Microbiology·K A Hoekstra, R J L Paulton
Sep 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kevin B Laupland, John M Conly
Dec 7, 2013·International Journal of Biomedical Imaging·Fatima SbeityJean-Marc Girault
Apr 14, 2007·Dermatologic Clinics·James Q Del Rosso, James J Leyden
Jul 25, 2003·Expert Opinion on Pharmacotherapy·David R P Guay
Feb 18, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S Subedi, K N Brahmadathan
Jan 27, 2004·Pharmacotherapy·Kerry L Tedesco, Michael J Rybak
May 3, 2021·Antimicrobial Resistance and Infection Control·Bahareh HajikhaniMasoud Dadashi

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