Abstract
The purpose of this study was to determine the mechanisms and patterns of antimicrobial resistance among the isolates obtained from burned patients with wound infections at a teaching hospital in Tehran, Iran. A total of 23 Acinetobacter baumannii isolates were collected from patients with burn wound infections between August 2009 and July 2010 from a hospital in Tehran. The susceptibility of these strains against 11 antimicrobial agents was determined by E-test according to the CLSI guidelines. All the resistant strains were then subjected to PCR assay for 28 distinct resistance genes. The most active antimicrobial agent was colistin with 100% sensitivity followed by gentamicin, amikacin and imipenem with 69.5%, 52.1% and 51.1% sensitivity, respectively. The most frequent resistance genes detected were bla(OXA-51-like) genes (n=23; 100%) that was intrinsic to A. baumannii isolates, gyrA (n=23; 100%), carO (n=23; 100%), tetA (n=22; 95.5%), tetB (n=15; 65.2%), intI (n=13; 56.5%) and PER (n=12; 52.1%), respectively. In order to make a proper choice of antibiotic for burn patients, it would be beneficial to physicians to identify drug resistance patterns in A. baumannii isolates.
References
Jun 1, 1997·The Journal of Antimicrobial Chemotherapy·J VilaT Jimenez de Anta
Jan 8, 1999·Journal of Medical Microbiology·R J SewardK J Towner
Apr 4, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G BouJ Martínez-Beltrán
Mar 9, 2004·Journal of Clinical Microbiology·Raffaele ZarrilliPaolo Villari
Jul 8, 2005·Journal of Clinical Microbiology·Jane F TurtonTyrone L Pitt
Sep 8, 2005·Journal of Clinical Microbiology·Nashwan Al NaiemiMenno D de Jong
Mar 28, 2006·International Journal of Antimicrobial Agents·Neil WoodfordDavid M Livermore
Sep 27, 2006·Antimicrobial Agents and Chemotherapy·Kristine M HujerRobert A Bonomo
Aug 19, 2007·BMC Infectious Diseases·Homer C TienAndrew Simor
Sep 12, 2007·Antimicrobial Agents and Chemotherapy·Hui WangYuanjue Zhu
Nov 13, 2007·Burns : Journal of the International Society for Burn Injuries·Harvey ChimColin Song
Dec 21, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K J TownerUNKNOWN ARPAC Steering Group
Dec 19, 2008·International Journal of Antimicrobial Agents·Kyungwon LeeUNKNOWN KONSAR Group
Apr 14, 2009·Diagnostic Microbiology and Infectious Disease·Young Kyoung ParkKwan Soo Ko
Jun 18, 2009·Annals of Clinical Microbiology and Antimicrobials·Vijaya B SrinivasanWondwossen A Gebreyes
Sep 15, 2009·Diagnostic Microbiology and Infectious Disease·Carlos Hernan RodriguezFamiglietti Angela
Sep 18, 2009·Journal of Infection in Developing Countries·Raffaele ZarrilliAthanassios Tsakris
Oct 28, 2009·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Anna PapaEfimia Souliou
Jan 19, 2010·Burns : Journal of the International Society for Burn Injuries·Edward F KeenClinton K Murray
Feb 4, 2010·American Journal of Infection Control·Karina Eugênia Schimith BierLibera Maria Dalla Costa
Jul 1, 2010·Acta Microbiologica Et Immunologica Hungarica·Mahdi AkbariHematian Ali
Jul 9, 2010·BMC Infectious Diseases·Lemuel L DentRobert B Hulette
Sep 28, 2010·American Journal of Infection Control·Marcelo CarneiroAfonso L Barth
Citations
Aug 26, 2014·Jundishapur Journal of Microbiology·Abdollah ArdebiliAbdolaziz Rastegar Lari
Jun 7, 2013·Nanomedicine·Liyi HuangMichael R Hamblin
Jul 17, 2014·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Abbas BahadorFarhad B Hashemi
Sep 26, 2014·Annals of Clinical Microbiology and Antimicrobials·Mohtaram NasrolaheiDavoud Esmaeili
Dec 17, 2014·Journal of Burn Care & Research : Official Publication of the American Burn Association·Andrew LindfordJyrki Vuola
Jun 27, 2015·Journal of Infection and Public Health·Somayeh MahdianMorovat Taherikalani
May 21, 2015·Journal of Medical Microbiology·Hadi FarsianiAli-Asghar Baghani
Jan 22, 2015·Burns : Journal of the International Society for Burn Injuries·Himen SalimizandSaeid Jamehdar Amel
Sep 24, 2015·Jundishapur Journal of Microbiology·Abbas BahadorDavood Esmaeili
Jun 4, 2013·Burns : Journal of the International Society for Burn Injuries·Omid PajandZoya Hojabri
May 6, 2015·Osong Public Health and Research Perspectives·Jale MoradiAbbas Bahador
Nov 5, 2014·Annals of Laboratory Medicine·Abdollah ArdebiliMalihe Talebi
Jan 14, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Hadi Razavi NikooJalal Mardaneh
Mar 31, 2015·International Journal of Immunopathology and Pharmacology·Abdolaziz Rastegar LariMorovat Taherikalani
Apr 22, 2016·The Open Microbiology Journal·Maryam PourhajibagherAbbas Bahador
Sep 20, 2019·BMC Research Notes·Mansoor KhalediAbolfazl Gholipour
Mar 8, 2017·Journal of the Chinese Medical Association : JCMA·Saeed ShojaNasim Ebrahimifard
Jul 21, 2017·Annals of Clinical Microbiology and Antimicrobials·Zahra MeshkatAdel Najafi
Oct 17, 2018·Antimicrobial Resistance and Infection Control·Marziyeh TavakolElahe Tajbakhsh
Oct 31, 2020·Frontiers in Microbiology·Siva R UppalapatiRanjana Pathania
Nov 19, 2020·Revista Do Instituto De Medicina Tropical De São Paulo·Maryam BeheshtiVeeranoot Nissapatorn
Sep 29, 2020·MethodsX·Mojtaba MoosavianMaryam Afzali
May 8, 2019·Journal of Global Antimicrobial Resistance·Fatemeh JavanmardiAbdolkhalegh Keshavarzi
Oct 16, 2021·Frontiers in Microbiology·Mahmoud M SherifNeveen A Abdelaziz