Antimicrobial Resistance Patterns in Women with Positive Urine Culture: Does Menopausal Status Make a Significant Difference?

BioMed Research International
Pawel MiotlaTomasz Rechberger

Abstract

Aim . Urinary tract infection (UTI) is considered one of the most common bacterial infections in women. The aim of this study was to investigate the types of uropathogens present, as well as the degree of antimicrobial drug resistance seen among premenopausal (n= 2748) and postmenopausal (n= 1705) women with uncomplicated UTI.Methods. Urinary samples (n= 4453) collected from women with UTI were analyzed in terms of uropathogens present. These were considered as positive if bacterial growth was ≥105colony forming units (CFUs)/mL. Susceptibility and resistance testing for commonly used antibiotics was subsequently assessed.Results. The most common uropathogens cultured from urine samples wereEscherichia coli(65.5%), followed byEnterococcus faecalis(12.2%),Klebsiella pneumoniae(4.7%), andProteus mirabilis(4.2%). The resistance to ampicillin exceeded 40%, independently of menopausal status. Of note, resistance to ciprofloxacin exceeded 25% among postmenopausal patients. Moreover, resistance of all uropathogens to commonly used antimicrobials was significantly higher in postmenopausal women.Conclusion. Due to the high resistance rate, ampicillin, ciprofloxacin, and the trimethoprim/sulfamethoxazole combination should be avoided in t...Continue Reading

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Citations

Oct 4, 2019·Central European Journal of Public Health·Zorana DjordjevićSlobodan Janković
Aug 18, 2020·Neurourology and Urodynamics·Megan S BradleyMary F Ackenbom
Aug 6, 2020·Antibiotics·Răzvan-Cosmin PetcaCălin Bogdan Chibelean
Sep 13, 2018·Journal of Clinical Medicine·Pawel MiotlaTomasz Rechberger
Nov 3, 2020·International Journal of Microbiology·Dhifar Raa'd Al-Guranie, Sareaa Maseer Al-Mayahie

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