Antimicrobial resistance prevalence, rates of hospitalization with septicemia and rates of mortality with sepsis in adults in different US states

International Journal of Antimicrobial Agents
Edward GoldsteinMarc Lipsitch

Abstract

Rates of hospitalization with sepsis/septicemia and associated mortality in the US have risen significantly during the last two decades. Antibiotic resistance may contribute to the rates of sepsis-related outcomes through lack of clearance of bacterial infections following antibiotic treatment during different stages of infection. However, there is limited information about the relationship between prevalence of resistance to various antibiotics in different bacteria and rates of sepsis-related outcomes. For different age groups of adults (18-49y, 50-64y, 65-74y, 75-84y, 85+y) and combinations of antibiotics/bacteria, we evaluated associations between state-specific prevalence (percentage) of resistant samples for a given combination of antibiotics/bacteria among catheter-associated urinary tract infections (CAUTIs) in the CDC Antibiotic Resistance Patient Safety Atlas data between 2011-2014, and rates of hospitalization with septicemia (ICD-9 codes 038.xx present on the discharge diagnosis) reported to the Healthcare Cost and Utilization Project (HCUP), as well as rates of mortality with sepsis (ICD-10 codes A40-41.xx present on death certificate). Among the different combinations of antibiotics/bacteria, prevalence of resista...Continue Reading

Citations

Mar 14, 2020·AACN Advanced Critical Care·Catherine G Ling, Jesus Casida
Dec 1, 2019·BMC Infectious Diseases·Gwenan M KnightKatherine E Atkins
Feb 24, 2020·BMC Infectious Diseases·Edward Goldstein, Marc Lipsitch
Jun 24, 2020·Infection and Immunity·John C AlverdyRenee Thewissen
Mar 13, 2021·Epidemiologic Reviews·Marlieke E A de Kraker, Marc Lipsitch
Aug 31, 2021·SAGE Open Medicine·Noura Al MansourKhalid M Bindayna

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