Abstract
The purpose of this study was to implement a targeted antimicrobial stewardship intervention for patients with a viral respiratory tract infection. This was a quasi-experimental before and after audit and feedback intervention of adult inpatients with a positive polymerase chain reaction for a respiratory virus in 2 acute care hospitals in Vancouver, Canada. Audit and feedback was implemented based on 2 criteria: microbiology (no positive bacterial cultures) and chest imaging (absence of pneumonia or consolidation on radiology dictation). A chart review was conducted to assess for days of antibiotics postviral diagnosis. Outcomes including length of stay, intensive care unit admission within 14 days, mechanical ventilation within 14 days, antibiotics prescribed within 14 days, Clostridium difficile infection diagnosed within 30 days, and readmission within 30 days were also reviewed in comparison with the previous year. Antimicrobial stewardship recommendations for hospitalized patients with viral respiratory tract infections were accepted for 77% of cases. This targeted approach based on easily assessed parameters translated into a 1.3-day (95% confidence interval, 0.3-2.3; P < .01) decrease in mean days of antibiotics postvir...Continue Reading
Citations
Apr 6, 2018·Expert Review of Anti-infective Therapy·Matthew W McCarthy, Thomas J Walsh
Mar 30, 2018·Journal of Clinical Microbiology·Amy L LeberBart Kensinger
May 3, 2019·Pharmacotherapy·Pavithra SrinivasElizabeth A Neuner
Jun 7, 2019·Hospital Pediatrics·Kim C NoëlJesse Papenburg
Apr 7, 2020·Journal of Medical Virology·Nancy MaticChristopher F Lowe
Mar 7, 2020·Journal of Clinical Microbiology·Amy L LeberIrene Hannet
May 2, 2019·Open Forum Infectious Diseases·Daniel B ChastainChristopher M Bland
Jun 22, 2017·The Journal of Infectious Diseases·Angela R Branche, Ann R Falsey
Mar 11, 2020·Canadian Journal of Kidney Health and Disease·Matthew KadatzChristopher F Lowe
Jun 30, 2019·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jing LiLynn N Fitzgibbons
Jul 31, 2019·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Monica L BianchiniSusan L Davis
Oct 23, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tony MoradiSarah Boyd
Oct 23, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tristan T Timbrook
Dec 2, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Michael KlompasMichael B Rothberg
Dec 6, 2020·Journal of Clinical Pharmacy and Therapeutics·Kelly CovertPaul O Lewis
Mar 9, 2021·Current Infectious Disease Reports·Theodore S RaderGonzalo Bearman
Oct 2, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E SaarelaM Renko
Jun 14, 2019·Current Opinion in Organ Transplantation·Fernando Dominguez, Emily Blodget
Nov 21, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jense WilsAnnette Schuermans
Sep 23, 2021·Pediatrics·Kayur MehtaUNKNOWN Canadian Immunization Monitoring Program Active (IMPACT) Investigators