Antimicrobial susceptibility and molecular analysis of Enterococcus faecalis originating from endodontic infections in Finland and Lithuania

Oral Microbiology and Immunology
A Reynaud af GeijersstamM Haapasalo

Abstract

Enterococcus faecalis strains with multiple antibiotic resistances can cause infections that are difficult to treat. The microbial flora in treatment-resistant apical periodontitis is dominated by E. faecalis, and is a potential source of infections at other sites. Sensitivities to a range of antibiotics were determined for 59 endodontic E. faecalis isolates from Finland and Lithuania. The DNA sequence of the gene responsible for the species' intrinsic quinupristin-dalfopristin resistance, lsa, was determined from two isolates with diminished resistance. Four pairs of isolates from the same root canal were typed by pulsed-field gel electrophoresis. A high prevalence of resistance to rifampicin was found, whereas all isolates were susceptible or showed intermediate susceptibility to penicillin and ampicillin and four isolates were unusually susceptible to cefotaxime. No vancomycin or high-level gentamicin resistance was detected. Nine of 59 isolates were susceptible to quinupristin-dalfopristin. A fully quinupristin-dalfopristin-susceptible isolate also susceptible to clindamycin produced a truncated Lsa polypeptide, and an isolate with borderline quinupristin-dalfopristin-susceptibility had mutations proximal to the predicted r...Continue Reading

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Citations

Dec 3, 2013·Indian Journal of Microbiology·Monika Eliza LysakowskaMonika Sienkiewicz
Oct 31, 2012·Journal of Periodontology·Thomas E RamsArie J van Winkelhoff
Apr 26, 2007·Annals of Medicine·Keith Poole
Sep 26, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Patricia PoetaCarmen Torres
Jan 25, 2008·Journal of Endodontics·Aguinaldo Silva GarcezMartha Simões Ribeiro
Mar 10, 2015·Journal of Endodontics·Ludmila Coutinho MoraesFrancisco Montagner
Jul 16, 2013·Journal of Dentistry·Renata Ximenes LinsRivail Antonio Sergio Fidel

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