Antimicrobial susceptibility and molecular epidemiology of Streptococcus pneumoniae isolated from Shanghai, China

International Journal of Antimicrobial Agents
Fan YangLesley McGee

Abstract

In this study, the antimicrobial resistance profiles of pneumococci isolated from respiratory specimens of patients from Shanghai, China, in 2004 and 2005 are described. Non-susceptible rates to penicillin and erythromycin among paediatric isolates (n=122) were 63.1% and 94.3%, respectively, whilst those of adult isolates (n=39) were 20.5% and 69.2%, respectively (P<0.0001 and P<0.0002). Nineteen serotypes were identified among 103 tested strains, 73.8% of which belonged to 19F, 14, 23F, 6B and 19A. The erm(B) gene was detected in 51 erythromycin-resistant strains (52.6%), the mef(E) gene in 5 strains (5.2%) and both erm(B) and mef(E) in 41 strains (42.3%). Among 45 sequence types (STs) determined by multilocus sequence typing (MLST) in these 103 isolates, 25 STs were new assignments and 9 STs contained 10 new alleles. On the other hand, 46 (68.7%) of 67 penicillin-non-susceptible S. pneumoniae and 51 (52.6%) of 97 macrolide-resistant S. pneumoniae were characterised as belonging to four international resistant clonal complexes, Taiwan(19F)-14, Spain(23F)-1, Spain(6B)-2 and Taiwan(23F)-15. Our findings indicate that the spread of international resistant clones played a predominant role in the emergence and increase of resistanc...Continue Reading

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Citations

Nov 27, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Ioanna N GriveaGeorge A Syrogiannopoulos
Oct 20, 2009·The Journal of Antimicrobial Chemotherapy·Elia Gómez G de la PedrosaRafael Cantón
Sep 2, 2011·Journal of Clinical Microbiology·Eileen M DunneCatherine Satzke
Oct 5, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Q GuoM Wang
Sep 25, 2012·International Journal of Antimicrobial Agents·Saber Yezli, Han Li
Jul 12, 2011·Tropical Medicine & International Health : TM & IH·Yoel LubellNicholas J White
Feb 3, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Nadja SpardingHans-Christian Slotved
Oct 16, 2009·Expert Opinion on Pharmacotherapy·M KleinU Koedel
Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Adnan MannanImtiaj Hasan

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