Antimicrobial susceptibility and molecular characterization of macrolide resistance of Mycoplasma bovis isolates from multiple provinces in China

The Journal of Veterinary Medical Science
Ling-Cong KongHong-Xia Ma

Abstract

Mycoplasma bovis has spread widely throughout the world via animal movement and has become an important pathogen of bovine respiratory disease. However, the minimum inhibitory concentrations of antimicrobials for Mycoplasma bovis have not been studied in China. The objective of this study was to determine the prevalence and antibiotic resistance of Mycoplasma bovis isolated from young cattle with respiratory infection in China. Mycoplasma bovis was detected in 32/45 bovine respiratory infection outbreaks at beef farms in 8 provinces in China. The isolates were susceptible or had medium sensitivity to ciprofloxacin, enrofloxacin and doxycycline, but were frequently resistant to macrolides (13/32, 41%). An A2058G (Escherichia coli Numbering) mutation located in the rrnA operon in domain V of 23S rRNA was observed in strains that were resistant to macrolides. This single mutations at the rrnA operon in domain V of 23S rRNA may play an important role in the resistance of Mycoplasma bovis strains to macrolides.

References

Nov 30, 2005·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Ricardo F RosenbuschLorraine J Hoffman
Jul 14, 2010·The Veterinary Clinics of North America. Food Animal Practice·Jeff L CaswellFernanda Castillo-Alcala
Apr 30, 2011·Future Microbiology·Cécile BébéarOlivia Peuchant
Sep 13, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Marty K SoehnlenBhushan M Jayarao
Jan 8, 2014·Veterinary Microbiology·Uri LernerInna Lysnyansky
Sep 28, 2014·The Journal of Antimicrobial Chemotherapy·Anders S OlsenStephen Douthwaite
Mar 4, 2015·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Inna LysnyanskySalvatore Catania

❮ Previous
Next ❯

Citations

May 21, 2016·Frontiers in Microbiology·Inna Lysnyansky, Roger D Ayling
Sep 2, 2018·The Veterinary Record
Feb 6, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Dima KhalilFlorence Tardy
Dec 10, 2020·Microbial Pathogenesis·Jiaqiang NiuDingren Bi
Jul 14, 2018·Microbiology Spectrum·Anne V Gautier-Bouchardon

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

ClustalW
DNASTAR

Related Concepts