Antimicrobial susceptibility of 80 Moraxella catarrhalis strains isolated in the children's hospital of Tunis

Pathologie-biologie
H KhemiriA Kechrid

Abstract

Eighty non-repetitive strains of Moraxella catarrhalis, isolated in Tunis Children's Hospital during five years from 1998 to 2002, were tested for their antimicrobial susceptibility, 95% of these strains were isolated from lung samples: 57.5% from trachea products, 35% from sputum and 2.5% from bronchial washings. The majority of strains (72%) were obtained from children under two years old. Antimicrobial susceptibility study showed that 95% of stains were beta-lactamase-producing, therefore they were penicillin G and amoxicillin resistant with high MICs. MIC(90) of penicillin G and amoxicillin of beta-lactamase-producing strains were respectively greater than 32 and 6 mg/l, these MIC decrease with addition of clavulanic acid. In fact, all strains studied were susceptible to the association amoxicillin-clavulanic acid as well as to cefotaxime. Concerning the other antimicrobial groups percentages of resistant strains found were as follows: erythromycin 3.75%, trimethoprim-sulfamethoxazol 12.5% and tetracycline 1.25%. Finally, all strains were susceptible to chloramphenicol, rifampicin and ciprofloxacin.

References

Nov 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J J ChristensenB Bruun
Sep 1, 1989·Antimicrobial Agents and Chemotherapy·B A BrownS D Redditt
Apr 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G M WoodJ G McCormack
May 1, 1997·Journal of Medical Microbiology·M C Enright, H McKenzie

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