Antimicrobial susceptibility of clinical isolates of Neisseria gonorrhoeae to alternative antimicrobials with therapeutic potential

The Journal of Antimicrobial Chemotherapy
P R S Lagacé-WiensGeorge G Zhanel

Abstract

The prevalence of MDR Neisseria gonorrhoeae is increasing globally and represents a public health emergency. Development and approval of new anti-gonococcal agents may take years. As a concurrent approach to developing new antimicrobials, the laboratory and clinical evaluation of currently licensed antimicrobials not widely used for the treatment of gonorrhoea may provide new options for the treatment of gonococcal infections. To determine the in vitro activity of nine alternative, currently licensed and late-development antimicrobials with the potential to treat gonococcal infections against 112 clinical isolates of N. gonorrhoeae resistant to one or multiple antimicrobials. The MICs of conventional anti-gonococcal antimicrobials (penicillin, ceftriaxone, cefixime, azithromycin, ciprofloxacin, tetracycline and spectinomycin) and alternative antimicrobials (ertapenem, gentamicin, netilmicin, tigecycline, eravacycline, fosfomycin, linezolid, ceftazidime/avibactam and ceftaroline) were determined by agar dilution. Ertapenem and the novel cephalosporins demonstrated similar MIC values to the third-generation cephalosporins, but increased MICs were observed for isolates with increased cefixime and ceftriaxone MICs. Tigecycline and ...Continue Reading

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Citations

Jan 29, 2019·The Journal of Antimicrobial Chemotherapy·Stefan RiedelJames E Kirby
Jan 31, 2019·Microbial Genomics·Leonor Sánchez-Busó, Simon R Harris
Jan 17, 2020·Pharmacotherapy·Sara AlosaimyMichael J Rybak
Oct 31, 2020·International Journal of STD & AIDS·M UnemoJ S Jensen
Jan 21, 2021·The Journal of Antimicrobial Chemotherapy·Helen FiferMichelle J Cole
Mar 4, 2020·Medicina clínica·Elizabeth Calatrava-HernándezJosé Gutiérrez-Fernández
Aug 16, 2021·International Journal of Antimicrobial Agents·George P AllenThomas Tran

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