Antimicrobial susceptibility of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae isolates causing meningitis in The Netherlands, 1993-1994

The Journal of Antimicrobial Chemotherapy
R H EntingJ Dankert

Abstract

The increasing antimicrobial resistance among pathogens frequently isolated from patients with bacterial meningitis formed the rationale to perform a surveillance study to determine the prevalence of resistance in The Netherlands. Haemophilus influenzae strains (n = 316) isolated from cerebrospinal fluid (CSF), 1125 meningococcal strains isolated from blood or CSF and 398 pneumococcal strains isolated from CSF in 1993 and 1994 were tested by the Etest for susceptibility to commonly prescribed antibiotics for the treatment of community-acquired meningitis. In H. influenzae strains ampicillin-resistance occurred in 7.0%, resistance to chloramphenicol in 2.2%, and resistance to both antibiotics in 0.9%. The prevalence of intermediate penicillin-resistance in meningococci was 3.3%. Resistance to rifampicin was rarely found (0.1%). Intermediate penicillin-resistance in pneumococci was found in only 0.5% of isolates. All 1839 isolates were susceptible to ceftriaxone. Based on these results, we conclude that empirical therapy of childhood community-acquired bacterial meningitis with amoxycillin and chloramphenicol is no longer justified in children who have not been vaccinated against H. influenzae type b. In vaccinated or older child...Continue Reading

Citations

Nov 15, 2002·The New England Journal of Medicine·Jan de GansUNKNOWN European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators
Feb 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paola MastrantonioStefania Salmaso
Sep 16, 2000·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·A SkoczyńskaW Hryniewicz
Mar 23, 2002·The Journal of Antimicrobial Chemotherapy·Diederik van de BeekJacob Dankert
Dec 22, 1999·Antimicrobial Agents and Chemotherapy·A BäckmanP Olcén
Mar 16, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M C BrouwerJ de Gans
Oct 19, 2007·The Cochrane Database of Systematic Reviews·K PrasadT Singhal

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