Abstract
We analyzed the antimicrobial susceptibilities of Haemophilus influenzae isolates from 157 sputum specimens prospectively collected from 39 cystic fibrosis (CF) patients during a 2-year study. These isolates were characterized by random amplified polymorphic DNA analysis and major outer membrane protein (MOMP) analysis to identify H. influenzae strains and MOMP variants and to assess their persistence in the respiratory tract. Among the 247 H. influenzae isolates, 16 (6.5%) produced beta-lactamase. The 231 beta-lactamase-negative isolates represented 85 H. influenzae strains, 61 MOMP variants derived from 27 of these strains, and 85 persistent isolates identical to strains or MOMP variants. All beta-lactamase-negative isolates were tested for susceptibility to ampicillin, amoxicillin-clavulanic acid, cefuroxime, cefotaxime, cefaclor, imipenem, tetracycline, and trimethoprim-sulfamethoxazole by disk diffusion testing. Eleven (13%) H. influenzae strains, 18 (30%) MOMP variants, and 30 (35%) persistent isolates were resistant to one or more of the antibiotics tested. Antimicrobial susceptibility was decreased among MOMP variants and persistent isolates compared to nonpersistent H. influenzae strains, and changes in susceptibility ...Continue Reading
References
Dec 1, 1978·Journal of Clinical Pathology·S I Dirks-Go, H C Zanen
Jun 1, 1992·Journal of Bacteriology·R SrikumarJ W Coulton
Sep 1, 1992·Journal of Clinical Microbiology·L V MöllerL van Alphen
May 1, 1992·The Journal of Antimicrobial Chemotherapy·M PowellY S Fah
Aug 1, 1991·The Journal of Antimicrobial Chemotherapy·M PowellJ D Williams
Nov 11, 1991·Diagnostic Microbiology and Infectious Disease·G V DoernJ A Washington
Dec 1, 1990·The Journal of Antimicrobial Chemotherapy·M Powell, D M Livermore
Nov 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F H KayserP Santanam
Jan 1, 1985·Pharmacology & Therapeutics·H Nikaido
Aug 1, 1988·The Journal of Infectious Diseases·K GroeneveldH C Zanen
Feb 1, 1988·Antimicrobial Agents and Chemotherapy·G V DoernL A Maher
Apr 1, 1972·Antimicrobial Agents and Chemotherapy·C H O'CallaghanA H Shingler
Aug 1, 1984·Journal of Medical Microbiology·D C Turk
Aug 1, 1984·Antimicrobial Agents and Chemotherapy·P M MendelmanA L Smith
Nov 1, 1983·The Journal of Antimicrobial Chemotherapy·J W CoultonD Dorrance
Jan 1, 1981·Reviews of Infectious Diseases·J E Pennington
Nov 1, 1995·The Journal of Infectious Diseases·L V MöllerL van Alphen
Jul 1, 1993·Journal of Clinical Microbiology·L V MöllerJ Dankert
Dec 1, 1994·The Journal of Antimicrobial Chemotherapy·G HusseyH Schaaf
Jul 1, 1994·Journal of Medical Microbiology·A van BelkumL van Alphen
Mar 1, 1994·Molecular Microbiology·B DuimJ Dankert
Aug 1, 1993·The Journal of Antimicrobial Chemotherapy·P A JamesD G White
Mar 1, 1996·Infection and Immunity·L VogelL vanAlphen
Apr 1, 1996·The Journal of Antimicrobial Chemotherapy·P A JamesS A Murray
Oct 1, 1996·The Journal of Antimicrobial Chemotherapy·M P Bajanca-LavadoM V Vaz Pato
Citations
Jun 19, 2002·Antimicrobial Agents and Chemotherapy·Henri DabernatChristophe Pasquier
May 9, 2002·British Medical Bulletin·P T Heath, A S Breathnach
Mar 16, 2019·American Journal of Respiratory and Critical Care Medicine·Jordana E Hoppe, Scott D Sagel
Jan 20, 2000·Current Medical Research and Opinion·H K JohansenN Høiby
Apr 9, 2004·Journal of Clinical Microbiology·Federico RománJosé Campos
Jan 30, 1999·Antimicrobial Agents and Chemotherapy·A G RegelinkL Van Alphen
Jan 31, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M H SalariM Mohammadypour