Antimicrobial susceptibility of Haemophilus influenzae in the respiratory tracts of patients with cystic fibrosis.

Antimicrobial Agents and Chemotherapy
L V MöllerJ Dankert

Abstract

We analyzed the antimicrobial susceptibilities of Haemophilus influenzae isolates from 157 sputum specimens prospectively collected from 39 cystic fibrosis (CF) patients during a 2-year study. These isolates were characterized by random amplified polymorphic DNA analysis and major outer membrane protein (MOMP) analysis to identify H. influenzae strains and MOMP variants and to assess their persistence in the respiratory tract. Among the 247 H. influenzae isolates, 16 (6.5%) produced beta-lactamase. The 231 beta-lactamase-negative isolates represented 85 H. influenzae strains, 61 MOMP variants derived from 27 of these strains, and 85 persistent isolates identical to strains or MOMP variants. All beta-lactamase-negative isolates were tested for susceptibility to ampicillin, amoxicillin-clavulanic acid, cefuroxime, cefotaxime, cefaclor, imipenem, tetracycline, and trimethoprim-sulfamethoxazole by disk diffusion testing. Eleven (13%) H. influenzae strains, 18 (30%) MOMP variants, and 30 (35%) persistent isolates were resistant to one or more of the antibiotics tested. Antimicrobial susceptibility was decreased among MOMP variants and persistent isolates compared to nonpersistent H. influenzae strains, and changes in susceptibility ...Continue Reading

References

May 1, 1992·The Journal of Antimicrobial Chemotherapy·M PowellY S Fah
Nov 11, 1991·Diagnostic Microbiology and Infectious Disease·G V DoernJ A Washington
Nov 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F H KayserP Santanam
Jan 1, 1985·Pharmacology & Therapeutics·H Nikaido
Apr 1, 1972·Antimicrobial Agents and Chemotherapy·C H O'CallaghanA H Shingler
Aug 1, 1984·Journal of Medical Microbiology·D C Turk
Aug 1, 1984·Antimicrobial Agents and Chemotherapy·P M MendelmanA L Smith
Nov 1, 1983·The Journal of Antimicrobial Chemotherapy·J W CoultonD Dorrance
Jan 1, 1981·Reviews of Infectious Diseases·J E Pennington
Dec 1, 1994·The Journal of Antimicrobial Chemotherapy·G HusseyH Schaaf
Aug 1, 1993·The Journal of Antimicrobial Chemotherapy·P A JamesD G White
Apr 1, 1996·The Journal of Antimicrobial Chemotherapy·P A JamesS A Murray

❮ Previous
Next ❯

Citations

May 9, 2002·British Medical Bulletin·P T Heath, A S Breathnach
Mar 16, 2019·American Journal of Respiratory and Critical Care Medicine·Jordana E Hoppe, Scott D Sagel
Jan 31, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M H SalariM Mohammadypour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.