Antimicrobial susceptibility testing of dermatophytes--comparison of the agar macrodilution and broth microdilution tests

Chemotherapy
M NiewerthD Abeck

Abstract

Fifty dermatophyte strains, recently obtained from clinical material, belonging to 4 different species were examined for their susceptibility to 5 systemic or topical antimycotic agents using both an agar macrodilution and a broth microdilution test. Antimycotics compared were griseofulvin, itraconazole, sertaconazole, terbinafine and ciclopiroxolamine. A comparison of the minimum inhibitory concentrations (MIC) clearly showed differences between the two test methods applied. For all 5 antimycotics, MIC data were three- to seventy-fold lower in the microdilution test system. These differences, depending on the test method, have to be taken into account when comparing MIC data in the literature or when relating the in vitro data to the tissue concentrations determined in vivo.

Citations

Oct 5, 2001·Clinical Microbiology Reviews·J H RexD W Warnock
Jul 10, 2004·Journal of Clinical Microbiology·M A GhannoumD W Warnock
Feb 27, 2003·Journal of Veterinary Pharmacology and Therapeutics·H Vanden BosscheF Rochette
Aug 18, 2009·Revista Da Sociedade Brasileira De Medicina Tropical·Crystiane Rodrigues Araújo MotaMaria do Rosário Rodrigues Silva
Dec 13, 2002·American Journal of Clinical Dermatology·Malcolm J M DarkesKaren L Goa
Dec 1, 2015·Iranian Journal of Biotechnology·Seyyed Amin Ayatollahi MousaviSanaz Hadizadeh

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