PMID: 8591652Nov 1, 1995Paper

Antimicrobial therapy for rheumatoid arthritis

Baillière's Clinical Rheumatology
M KloppenburgF C Breedveld

Abstract

New interest in the use of antibiotics in the treatment of arthritis was stimulated by two factors: (1) observations that, in some forms of chronic arthritis, microbial antigens persist in the synovial membrane, and (2) the increasing knowledge of the anti-inflammatory and immunosuppressive effects of antibiotics. Recently, several published controlled studies reported a beneficial effect of tetracyclines on RA and reactive arthritis. Whether the anti-arthritic activity of the tetracyclines investigated is mediated by the antimicrobial, anti-inflammatory or immunomodulatory properties remains to be determined. It may be concluded from these studies that tetracyclines have a beneficial effect on RA, especially when laboratory parameters are considered. The effect on the clinical parameters is not unequivocal. The adverse effects seem to be mild but the long-term efficacy and safety of tetracyclines as disease-modifying antirheumatic drugs remain to be demonstrated.

References

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Citations

Jul 18, 2001·Springer Seminars in Immunopathology·N Fathy, D E Furst
Jan 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ji-Hye SeoSeung-Sik Cho
Nov 28, 2006·Best Practice & Research. Clinical Rheumatology·Rauli Franssila, Klaus Hedman
May 23, 2002·Brain : a Journal of Neurology·Veronika BrundulaV Wee Yong
May 5, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·J SuemitsuY Yamashita
Aug 1, 1996·Artificial Organs·Y Takenaka
Apr 22, 1999·Arthritis and Rheumatism·S C BallaraP J Venables
May 1, 1997·Arthritis and Rheumatism·F C Breedveld

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