Antimicrobial therapy in periodontitis: the use of systemic antimicrobials against the subgingival biofilm

Journal of Clinical Periodontology
David HerreraM Sanz

Abstract

The aim was to answer three relevant questions: can systemic antimicrobials be efficacious if the biofilm is not disrupted? Can the type of debridement of the subgingival biofilm impact upon the clinical outcomes of the adjunctive antimicrobial therapy? Is the efficacy of the adjunctive systemic antimicrobial therapy dependent on the quality of the debridement of the subgingival biofilm and the sequence debridement-antibiotic usage? Relevant papers were searched, critically analysed and their data were extracted. For the first question, studies assessing susceptibility of bacteria in biofilms, and clinical studies evaluating systemic antimicrobials as monotherapy, were reviewed. For the second question, clinical studies comparing systemic antimicrobials as adjuncts to non-surgical debridement or to periodontal surgery and clinical trials using systemic antibiotics with periodontal surgery were evaluated. For the third question, a previous systematic review was updated. If systemic antimicrobials are indicated in periodontal therapy, they should be adjunctive to mechanical debridement. There is not enough evidence to support their use with periodontal surgery. Indirect evidence suggests that antibiotic intake should start on the...Continue Reading

References

Aug 1, 1979·Journal of Clinical Periodontology·L B HelldénJ Lindhe
Feb 1, 1992·Journal of Clinical Periodontology·W J LoescheB A Smith
Apr 1, 1991·Journal of Periodontology·W J LoescheP P Hujoel
Aug 1, 1989·Journal of Clinical Periodontology·W M JenkinsD MacKenzie
Oct 1, 1989·Journal of Periodontology·W Al-JoburiE C Chan
Jul 1, 1988·The Journal of Antimicrobial Chemotherapy·T Chin QueeF Delorme
Mar 1, 1987·Journal of Periodontology·M M Mahmood, A E Dolby
Nov 1, 1986·Journal of Clinical Periodontology·T WattsP Floyd
Nov 1, 1986·Journal of Clinical Periodontology·S Joyston-BechalR Duckworth
Aug 1, 1985·Journal of Periodontology·K S Kornman, P B Robertson
Jan 1, 1974·Journal of Clinical Periodontology·E A Kidd, A B Wade
Jan 1, 1984·Journal of Clinical Periodontology·S Joyston-BechalR Duckworth
Jul 1, 1984·Journal of Clinical Periodontology·J Lindhe, B Liljenberg
Jan 1, 1983·Journal of Clinical Periodontology·J LindheI Börjesson
Jul 1, 1983·Journal of Periodontology·P D Pack, J Haber
Nov 1, 1983·Journal of Clinical Periodontology·J LindheB Adielsson
May 1, 1982·Journal of Periodontology·M D ApplemanT N Sims
Oct 1, 1994·Journal of Clinical Periodontology·I MagnussonW B Clark
Aug 1, 1993·Journal of Clinical Periodontology·H P MüllerR F Müller
Aug 1, 1993·Journal of Periodontology·C B WalkerW B Clark
Jan 1, 1993·Journal of Periodontology·G Greenstein
Mar 1, 1993·Journal of Clinical Periodontology·L Saxén, S Asikainen
Jul 1, 1996·Journal of Clinical Periodontology·R M PalmerR F Wilson
Jan 28, 1998·Journal of Periodontology·T MaliziaM Del Tacca
Feb 1, 1996·Periodontology 2000·T J Pallasch, J Slots
Jun 1, 1997·Periodontology 2000·R P DarveauR C Page

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Citations

Oct 18, 2011·Lasers in Medical Science·Fabrizio SgolastraAnnalisa Monaco
Jun 23, 2012·British Dental Journal·P D Marsh
Feb 15, 2012·Antimicrobial Agents and Chemotherapy·Kabilan VelliyagounderDaniel H Fine
Aug 4, 2012·Journal of Applied Oral Science : Revista FOB·Geisla Mary Silva SoaresMagda Feres
May 11, 2013·Journal of Periodontology·Georgios N Belibasakis, Thomas Thurnheer
Jul 23, 2013·Clinical Oral Investigations·Julia C SchmidtClemens Walter
Jun 16, 2014·The Journal of Evidence-based Dental Practice·Connie L Drisko
Jan 14, 2016·Archives of Oral Biology·Fernando VerdugoAgurne Uribarri
Oct 3, 2015·Dental Clinics of North America·John Walters, Pin-Chuang Lai
May 3, 2016·The Journal of Evidence-based Dental Practice·David Herrera
May 19, 2009·International Journal of Medical Microbiology : IJMM·Giuseppe ValenzaUlrich Vogel
Dec 15, 2015·Lasers in Surgery and Medicine·Mônica Grazieli CorrêaRenato Corrêa Viana Casarin
Nov 3, 2009·Periodontology 2000·Iain L C Chapple
Nov 3, 2009·Periodontology 2000·Per E Gjermo, Jostein Grytten
Sep 10, 2009·Australian Dental Journal·L J A Heitz-Mayfield
Aug 31, 2012·Journal of Clinical Periodontology·Dennis BeliveauLuciana M Shaddox
Feb 26, 2011·Journal of Clinical Periodontology·Sven-Ulrik Gorr, Mahsa Abdolhosseini
Apr 30, 2016·Indian Journal of Pharmacology·Sajith Abdul LatifPriyanka Jairaj Dalvi
Dec 8, 2010·Periodontology 2000·Andrea MombelliAdnan Almaghlouth
Dec 8, 2010·Periodontology 2000·Alex B Berezow, Richard P Darveau
May 24, 2012·Gerodontology·Takako NakajimaKazuhisa Yamazaki
Nov 19, 2011·Journal of Clinical Periodontology·Zhiqiang LiuZuomin Wang

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