Antimicrobial use in a critical care unit: a prospective observational study

The International Journal of Pharmacy Practice
Christina L CandeloroAnne Marie Bombassaro

Abstract

The purpose of this study was to describe antimicrobial utilization, consumption, indications and microbial resistance in a medical-surgical-trauma intensive care unit (ICU) of a teaching hospital to identify potential targets for antimicrobial stewardship. This was a 30-day prospective observational study enrolling adults admitted to the ICU for at least 24 h and having received antimicrobial therapy. Primary endpoints included utilization as percentage use of antimicrobials by class and agent, consumption measured as days of therapy per 1000 patient days (DOT/1000PD), indications for use and prescriber. Secondary endpoints included reasons for modifications to therapy and microbial resistance. Eighty-three patients were screened and 61 enrolled, receiving 133 courses of antimicrobial therapy, mainly intravenously and prescribed by ICU staff. The most frequently prescribed agents were piperacillin/tazobactam (20%), cefazolin (17%) and vancomycin (13%). The indications for therapy were empirical (50%), directed (27%) and prophylactic (23%). Overall consumption was 1368.54 DOT/1000PD and was mainly attributed to empirical therapy (734.25). Prolonged durations were noted for carbapenems and for surgical prophylaxis. There were 86...Continue Reading

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Citations

Mar 9, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Sean L BarnesKerri A Thom
Jan 2, 2019·Antimicrobial Resistance and Infection Control·Hanan H BalkhyAdel F Alothman
Dec 15, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Markus Harboe OlsenKirsten Møller

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