Antimicrobials Are a Photodynamic Inactivation Adjuvant for the Eradication of Extensively Drug-Resistant Acinetobacter baumannii

Frontiers in Microbiology
Agata WozniakMariusz Stanislaw Grinholc

Abstract

The worldwide emergence of extensively drug resistant (XDR) Acinetobacter baumannii has reduced the number of antimicrobials that exert high bactericidal activity against this pathogen. This is the reason why many scientists are focusing on investigations concerning novel non-antibiotic strategies such as antimicrobial photodynamic inactivation (aPDI) or the use of antimicrobial blue light (aBL). Therefore, the aim of the current study was to screen for antimicrobial synergies of routinely used antibiotics and phototherapies, including both aPDI involving exogenously administered photosensitizing molecules, namely, rose bengal, and aBL, involving excitation of endogenously produced photoactive compounds. The synergy testing was performed in accordance with antimicrobial susceptibility testing (AST) standards, including various methodological approaches, i.e., antibiotic diffusion tests, checkerboard assays, CFU counting and the evaluation of postantibiotic effects (PAEs). We report that combining antimicrobials and aPDI/aBL treatment led to a new strategy that overcomes drug resistance in XDR A. baumannii, rendering this pathogen susceptible to various categories of antibiotics. Sublethal aPDI/aBL treatment in the presence of s...Continue Reading

References

Jan 1, 1979·American Journal of Clinical Pathology·A L Barry, R A Lasner
May 22, 1998·Journal of Photochemistry and Photobiology. B, Biology·Y NitzanH Ashkenazi
Aug 13, 1998·The Journal of Antimicrobial Chemotherapy·M Wainwright
Jan 4, 2001·International Journal of Antimicrobial Agents·I Odenholt
Jun 14, 2003·The Journal of Antimicrobial Chemotherapy·F C Odds
Feb 10, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Raquel ValenciaJavier Aznar
Jul 1, 2009·Antimicrobial Agents and Chemotherapy·Tianhong DaiMichael R Hamblin
Feb 18, 2010·Molecular Cell·Michael A KohanskiJames J Collins
Sep 3, 2010·Investigative Ophthalmology & Visual Science·Min-Hsiu Shih, Fu-Chin Huang
Jul 29, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A-P MagiorakosD L Monnet
Mar 21, 2012·Antimicrobial Agents and Chemotherapy·Joe LatimerAndrew J McBain
Mar 24, 2012·The Journal of Antimicrobial Chemotherapy·Yun CaiNan Bai
Feb 13, 2014·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Joana AlmeidaAdelaide Almeida
Apr 17, 2014·Critical Care Medicine·Brad Spellberg, Robert A Bonomo
May 28, 2014·Nature Reviews. Microbiology·Dan I Andersson, Diarmaid Hughes
Jun 13, 2014·Journal of Clinical Microbiology·Christopher D Doern
Jun 23, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Tim Maisch
Jan 17, 2017·Trends in Microbiology·Heleen Van Acker, Tom Coenye
Jan 9, 2018·Photodiagnosis and Photodynamic Therapy·Tatiana Moura BrancoAdelaide Almeida
Feb 24, 2018·Journal of Photochemistry and Photobiology. B, Biology·Ming-Yeh YangAnren Hu
May 10, 2018·PloS One·Ya HeMichael R Hamblin
Jun 6, 2018·Frontiers in Microbiology·Agata Wozniak, Mariusz Grinholc

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Citations

Sep 10, 2020·International Journal of Environmental Research and Public Health·Katharina HoenesMartin Hessling
Apr 25, 2021·Applied Microbiology and Biotechnology·Baobao LiuGuoqiang Zhu
Jul 8, 2021·Photodiagnosis and Photodynamic Therapy·Adenilson de Souza da FonsecaFlavia de Paoli

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