PMID: 16515529Mar 7, 2006Paper

Antimitotic agents of natural origin

Current Drug Targets
Advait NagleNathanael S Gray

Abstract

Antimitotic agents have been the most successful pharmacological agents for the treatment of cancer. The term "antimitotic agent" has traditionally been synonymous with tubulin-targeting compounds, but as a consequence of the large number of new compounds and mechanisms that have been identified recently, a much broader definition is currently needed. This review attempts to provide a broad overview of compounds and their cognate protein targets which result in a block in mitosis. Focus has been placed on agents that act directly on the mitotic machinery rather than on targets further upstream such as growth factor receptors.

Citations

Apr 12, 2008·Journal of Natural Medicines·Valery M Dembitsky
Nov 22, 2008·Natural Product Research·Ana R Díaz-MarreroRaymond J Andersen
Aug 9, 2007·Future Microbiology·Barbara Kappes, Petra Rohrbach
Jul 9, 2014·PloS One·James J La ClairPhillip Crews
Nov 5, 2014·Chemical Reviews·Advait S NagleValentina Molteni
May 5, 2011·Journal of Pharmacological and Toxicological Methods·N R MonksJ M Littleton
Aug 19, 2015·Natural Product Reports·Jamie E SmythPaul A Keller
Aug 9, 2007·Chemical Biology & Drug Design·Zhiyong WangPeter Wipf
Nov 14, 2006·Analytical Biochemistry·Shubhada SharmaSusan Bane
Oct 26, 2010·Analytical Biochemistry·Juan FengFei Liao
Nov 3, 2016·Oxidative Medicine and Cellular Longevity·Jaqueline Ferreira CamposEdson Lucas Dos Santos
Feb 12, 2017·Chemical Biology & Drug Design·Hua-Li QinSyed Nasir Abbas Bukhari
Jun 28, 2017·Biomedicines·Olusiji A AkinrinmadeStefan Barth
Jul 30, 2019·Journal of Receptor and Signal Transduction Research·Yaping QiuYinfeng Bao
Feb 6, 2016·The Biochemical Journal·Wei ZhangYonghe Li
Jun 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicole S StiversPaula J Bates
Mar 28, 2017·Future Science OA·Ashok K SinghSudipta Saha
Feb 26, 2008·Journal of Medicinal Chemistry·Ahcène BoumendjelCharles Dumontet

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