Antimitotic intervention with colchicine alters the outcome of o-DCB-induced hepatotoxicity in Fischer 344 rats

Toxicology
S G KulkarniH M Mehendale

Abstract

Although, hepatotoxic injury of 1,2-dichlorobenzene (o-DCB) is greater in Fischer 344 (F344) as compared to Sprague-Dawley (S-D) rats, this interstrain difference does not transcend into any difference in lethal effects of o-DCB. Interstrain difference in compensatory tissue repair has been suggested as the underlying mechanism for the lack of strain differences in lethality (S.G. Kulkarni, H. Duong, R. Gomila, and H.M. Mehendale, Strain differences in tissue repair response to 1,2-dichlorobenzene. Archives of Toxicology 1996; 70: 714-723). If higher tissue repair in F344 rats compensates for more severe liver injury, then antimitotic intervention after infliction of o-DCB-induced liver injury should lead to lethality in F344 rats. Colchicine (CLC, 1 mg/kg) functions as an effective antimitotic agent and does not cause any side effects apart from suppressing cellular proliferation. Two groups of male F344 rats (160-190 g) received a single dose of 0.6 ml o-DCB/kg: 30 h later one group of rats received CLC (1 mg/kg; i.p.) and the other received distilled water (1 ml/kg; i.p.). Liver injury was assessed by measuring plasma ALT and SDH activity, liver histopathology, and liver regeneration was estimated by [3H]thymidine incorporat...Continue Reading

References

Feb 1, 1978·Archives of Biochemistry and Biophysics·J A Koehn, R W Olsen
Jun 1, 1975·The Journal of Infectious Diseases·J M BrogardJ Lavillaureix
Nov 27, 1991·Biochemical Pharmacology·C V Rao, H M Mehendale
Jan 1, 1991·Toxicologic Pathology·V C Rao, H M Mehendale
Oct 1, 1990·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·S D Ray, H M Mehendale
Nov 2, 1989·Biochimica Et Biophysica Acta·I Tsukamoto, S Kojo
Sep 1, 1971·Toxicology and Applied Pharmacology·G J Traiger, G L Plaa
Mar 1, 1967·Archives of Environmental Health·H H Cornish, J Adefuin
Jan 1, 1984·Pharmacology & Therapeutics·J J Manfredi, S B Horwitz
Aug 1, 1983·Experimental and Molecular Pathology·J S KlingensmithH M Mehendale
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S ChandaH M Mehendale
Jan 1, 1993·Archives of Toxicology·V C Rao, H M Mehendale
Jul 1, 1996·Environmental Health Perspectives·R S MangipudyH M Mehendale
Sep 1, 1995·Pharmacology & Toxicology·R S MangipudyH M Mehendale
Jan 1, 1996·Archives of Toxicology·S G KulkarniH M Mehendale
Aug 1, 1956·Experimental Cell Research·J CHAUVEAUC ROUILLER

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Citations

Jun 19, 2004·Archives of Pharmacal Research·Woon-Gye Chung, Donald R Buhler
Apr 15, 2003·Toxicology and Applied Pharmacology·Kartik ShankarHarihara M Mehendale
Dec 23, 1998·Environmental Health Perspectives·M G Soni, H M Mehendale
May 23, 2001·Archives of Biochemistry and Biophysics·P R SinclairJ F Sinclair
Feb 15, 2007·Toxicology·Sharmilee P SawantHarihara M Mehendale
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shashikiran DonthamsettyHarihara M Mehendale
Nov 1, 2004·Environmental Toxicology and Pharmacology·Sathanandam S AnandHarihara M Mehendale
Nov 1, 2004·Environmental Toxicology and Pharmacology·Sathanandam S Anand, Harihara M Mehendale
May 15, 2001·Toxicology and Applied Pharmacology·T WangH M Mehendale
May 27, 2008·Toxicology and Applied Pharmacology·Shashikiran DonthamsettyHarihara M Mehendale
Jul 7, 2007·Critical Reviews in Toxicology·T WangH M Mehendale
Apr 5, 2005·Toxicologic Pathology·Harihara M Mehendale
Feb 8, 2003·International Journal of Toxicology·Sathanandam S AnandHarihara M Mehendale
Feb 24, 2006·American Journal of Physiology. Renal Physiology·Midhun C KorrapatiHarihara M Mehendale
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kartik ShankarHarihara M Mehendale

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