Antimony concentrations in nodal tissue can confirm sentinel node identity

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Richard A ScolyerStanley W McCarthy

Abstract

The sentinel node biopsy procedure is a highly accurate method of staging patients with cutaneous melanoma and the tumor-harboring status of sentinel nodes is the most important prognostic factor. For the procedure to provide accurate prognostic information, however, it is essential that 'true' sentinel nodes are removed and examined thoroughly. A technique to confirm sentinel node identity may reduce the false-negative rate of the procedure. We have found that antimony (originating from the antimony sulfide colloid used for preoperative lymphoscintigraphy in our institution) can be measured in tissue sections of sentinel nodes using inductively coupled plasma mass spectrometry. The aims of this study were to determine whether antimony concentrations can be used to confirm that removed sentinel nodes are 'true' sentinel nodes and to differentiate sentinel nodes from nonsentinel nodes. In all, 24 patients who had both a tumor-positive sentinel node and a tumor-negative nonsentinel node removed from one regional node field during the same operation, were identified. Tissue sections (50 microm) thick were cut from archival paraffin blocks of each of the sentinel nodes and nonsentinel nodes. Antimony concentrations in the tissue se...Continue Reading

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Citations

Aug 29, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Annette H ChakeraUNKNOWN European Association of Nuclear Medicine-European Organisation for Research and
Aug 8, 2008·Future Oncology·Rajmohan MuraliRichard A Scolyer
Jan 29, 2010·The Lancet Oncology·Rajmohan MuraliRichard A Scolyer
Aug 14, 2008·Seminars in Diagnostic Pathology·Richard A ScolyerJohn F Thompson
Jul 22, 2008·Surgical Oncology·Richard A ScolyerJohn F Thompson
Aug 23, 2011·Journal of Surgical Oncology·Duan-Ren WenScott Binder
Sep 11, 2008·Melanoma Research·Marc MoncrieffJonathan Stretch

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