Antimony transport mechanisms in resistant leishmania parasites

Biophysics Reviews
Frédéric FrézardPriscila G Reis

Abstract

Antimonial compounds have been used for more than a century in the treatment of the parasitic disease leishmaniasis. Although pentavalent antimonials are still first-line drugs in several developing countries, this class of drugs is no longer recommended in the Indian sub-continent because of the emergence of drug resistance. The precise mechanisms involved in the resistance of leishmania parasites to antimony are still subject to debate. It is now well documented that drug resistance in leishmania parasites is a multifactorial phenomenon involving multiple genes whose expression pattern synergistically leads to the resistance phenotype. The reduction of intracellular antimony accumulation is a frequent change observed in resistant leishmania cells; however, no comprehensive transport model has been presented so far to explain this change and its contribution to Leishmania resistance. The present review firstly covers the actual knowledge on the metabolism of antimonial drugs, the mechanisms of their transmembrane transport and intracellular processing in Leishmania. It further describes both the functional and molecular changes associated with Sb resistance in this organism. Possible transport models based on the actual knowle...Continue Reading

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Citations

May 11, 2016·Antimicrobial Agents and Chemotherapy·Juvana M AndradeSilvane M F Murta
Aug 3, 2017·Clinical and Translational Medicine·Michael BiagiottiRachel Zufferey
Apr 23, 2020·Journal of Clinical Laboratory Analysis·Majid MirzaeeHamidreza Joshaghani
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Jun 20, 2020·The Journal of Physical Chemistry. B·Lucas S M NeumannMunir S Skaf

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