Antimüllerian hormone levels decrease in female-to-male transsexuals using testosterone as cross-sex therapy

Fertility and Sterility
Mirte R CaanenCornelis B Lambalk

Abstract

To investigate the effect of hormonal androgenic treatment on antimüllerian hormone (AMH) serum levels in female-to-male (FtM) transsexuals. Polycystic ovary syndrome (PCOS) is associated with elevated AMH levels. Some hypothesize that the high AMH level is a consequence of androgen-induced excessive development of small antral follicles. However, this role of androgens is not yet clear. Observational, prospective, cohort study. Tertiary academic medical center. Twenty-two FtM transsexuals, healthy native females receiving cross-sex hormone therapy/androgenic treatment. Androgenic treatment with testosterone (T) and an aromatase inhibitor while endogenous hormone secretion was suppressed with the use of a GnRH agonist. Hormone concentrations were measured before and after androgenic treatment (administration of T and aromatase inhibitor). Measured hormones: AMH, inhibin B, T, androstenedione, DHEAS, E2, SHBG, LH, and FSH. AMH concentrations were significantly lower after androgenic treatment (4.4 ± 4.4 μg/L vs. 1.4 ± 2.1 μg/L). Androgenic treatment resulted in a strong suppression of AMH secretion over a relative short period of 16 weeks. Our data underscore the likely important role of androgens in the dynamics of folliculogen...Continue Reading

References

Jun 1, 1993·Early Human Development·N JossoR Jeny
Apr 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·M Tetsuka, S G Hillier
Jun 24, 1998·The Journal of Clinical Investigation·K A VendolaC A Bondy
Aug 26, 1998·Journal of Reproduction and Fertility·A A MurrayN Spears
Aug 12, 1999·The Journal of Clinical Endocrinology and Metabolism·S WeilC A Bondy
Nov 6, 2002·Reproduction : the Official Journal of the Society for the Study of Fertility·Alexandra L L DurlingerAxel P N Themmen
Nov 29, 2002·Human Reproduction·I A J van RooijA P N Themmen
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Joop S E LavenBart C J M Fauser
Apr 20, 2005·Molecular and Cellular Endocrinology·Jenny A Visser, Axel P N Themmen
Jan 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Jenny A VisserAxel P N Themmen
Sep 19, 2006·Fertility and Sterility·Kamel Abdelhakim MohamedHany Lashen
Oct 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Laura PellattHelen Mason
Dec 23, 2006·Endocrine·F J Broekmans, B C J M Fauser
Feb 8, 2007·JAMA : the Journal of the American Medical Association·Janet M TorpyRichard M Glass
May 15, 2007·Endocrinology·Louise ManneråsElisabet Stener-Victorin
Dec 20, 2007·Ultrasound Quarterly·Michele A Brown, R Jeffrey Chang
May 7, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S Franks
Jun 14, 2008·Journal of Pediatric and Adolescent Gynecology·R F O'Brien, S J Emans
Sep 23, 2008·Trends in Endocrinology and Metabolism : TEM·Frank J BroekmansBart C Fauser
Dec 11, 2008·The Journal of Clinical Endocrinology and Metabolism·Erik A H KnauffUNKNOWN Dutch Premature Ovarian Failure Consortium
Jun 5, 2010·Fertility and Sterility·Karl R HansenLaTasha B Craig
May 10, 2011·Fertility and Sterility·Yi-Hui LinMing-I Hsu
Oct 2, 2013·The Journal of Clinical Endocrinology and Metabolism·H Irene SuHadine Joffe
Jan 17, 2014·Human Reproduction Update·Didier DewaillyRichard A Anderson
Jul 10, 2014·ISRN Obstetrics and Gynecology·Catiele Garcia GervásioAna Carolina Japur de Sá Rosa-E-Silva

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Citations

Feb 3, 2016·International Review of Psychiatry·Chloë De RooPetra De Sutter
Oct 5, 2018·Clinical Obstetrics and Gynecology·Molly B Moravek
Oct 12, 2018·Endocrine Reviews·Guy T'SjoenVin Tangpricha
Aug 23, 2019·Journal of Assisted Reproduction and Genetics·Amanda J AdeleyeEvelyn Mok-Lin
Oct 22, 2019·Human Reproduction Update·Shira BaramClifford L Librach
Mar 15, 2019·Current Opinion in Obstetrics & Gynecology·Molly B Moravek
Dec 22, 2019·International Journal of Environmental Research and Public Health·Jesús Manuel García-AcostaMaria Elisa Castro-Peraza
Feb 28, 2020·Endocrinology·Molly B MoravekJohn F Randolph
Oct 23, 2019·The Journal of Applied Laboratory Medicine·Robert M HumbleMatthew D Krasowski
Aug 17, 2020·The Journal of Clinical Endocrinology and Metabolism·Allison C Mayhew, Veronica Gomez-Lobo
Mar 17, 2019·International Journal of Environmental Research and Public Health·Maria-Elisa de Castro-PerazaNieves Doria Lorenzo-Rocha
Jul 29, 2020·Journal of Assisted Reproduction and Genetics·Hadar AmirFoad Azem
Sep 25, 2017·The Journal of Clinical Endocrinology and Metabolism·Alice PierreChrystèle Racine
May 21, 2020·Journal of Assisted Reproduction and Genetics·Hadar AmirAvi Ben-Haroush
Oct 6, 2020·Frontiers in Endocrinology·Didier DewaillyGeoffroy Robin
Mar 12, 2019·Current Opinion in Obstetrics & Gynecology·Pedro Montoya-BoteroNikolaos P Polyzos
Nov 27, 2020·The Journal of Applied Laboratory Medicine·Dina N GreeneMatthew D Krasowski
Feb 10, 2021·International Journal of Impotence Research·Ilaria ManciniMaria Cristina Meriggiola
May 11, 2021·Plastic and Reconstructive Surgery. Global Open·Oscar J ManriqueHoward N Langstein
Jun 27, 2021·Current Opinion in Obstetrics & Gynecology·Amanda R Schwartz, Molly B Moravek

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