Antimutagenic action of the triterpene betulinic acid isolated from Scoparia dulcis (Scrophulariaceae)

Genetics and Molecular Research : GMR
P L de FreitasS R F Pereira

Abstract

The mutagenic and antimutagenic activities of triterpene betulinic acid {3b-3-hydroxy-lup-20(29)-en-28-oic} isolated from the roots of Scoparia dulcis (Scrophulariaceae) were analyzed using the somatic mutation and recombination test (SMART) in the wings of Drosophila melanogaster. The mutagenic potential of betulinic acid was evaluated at 3 different concentrations (1.64, 3.28, and 6.57 mM). Antimutagenic activity evaluation was performed by co-treatment trials in which the flies received betulinic acid at 3 different concentrations in addition to 10 mM pro-mutagenic urethane. The results demonstrated that betulinic acid was not capable of causing DNA damage. However, the frequency of small single spots, large spots, and twin spots was significantly reduced. In the high bioactivation cross, betulinic acid was significantly active and exerted enhanced antimutagenic activity, possibly as a desmutagen.

Citations

Sep 11, 2016·Molecular Nutrition & Food Research·Gordon J McDougallChris I R Gill
Mar 1, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Victor Constante OliveiraMário Antônio Spanó

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