PMID: 8950351Nov 4, 1996Paper

Antimutagenic activity of extracts from Japanese eggplant

Mutation Research
K YoshikawaD M Shankel

Abstract

Using the Salmonella/microsome assay, the antimutagenic effects of specific components of the extracts from eggplant fruits were investigated. The eggplant fruit juice exhibited an antimutagenic activity against 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) induced mutagenicity. In some of the fractions extracted with several organic solvents (acetone, petroleum ether, ethyl acetate; and methanol), the activity was recognized. No mutagenicity or toxicity for Salmonella typhimurium TA98 in the presence of S9 mixture was observed with any of the extracts. It is suggested that there are multiple components of the activities that exist in the eggplant fruit. We isolated lutein from the 84% methanol (methanol/water, v/v) layer, pheophorbide or chlorophyllide from the 70% methanol layer and tannins containing sugar-moieties from the water layer. Pheophytin a and b, Mg-free derivatives of chlorophyll a and b, were isolated from the petroleum ether layer as possible antimutagens. The pheophytin a with S9 mix inhibited by 30-40% the mutagenicity of Trp-P-2.

Citations

Dec 10, 1999·Teratogenesis, Carcinogenesis, and Mutagenesis·E A VarandaD C Tavares
Jul 16, 2013·Applied Biochemistry and Biotechnology·Kondeti SubramanyamAndy Ganapathi
Jun 18, 2002·Journal of Ethnopharmacology·Eliana Aparecida VarandaMaria Stella Gonçalves Raddi
Jul 16, 2013·BioMed Research International·Maryam ZahinIqbal Ahmad
Oct 9, 2007·Journal of Ethnopharmacology·Ratchadaporn OonsivilaiSuwayd Ningsanond
May 24, 2014·Journal of Applied Toxicology : JAT·Peter Kovacic, Ratnasamy Somanathan
Mar 15, 2019·Natural Products and Bioprospecting·Joseph Sakah Kaunda, Ying-Jun Zhang
Oct 16, 2001·Journal of Agricultural and Food Chemistry·G C YenY L Hung

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