PMID: 2511444Dec 1, 1989Paper

Antimutagenic effect of garlic (Allium sativum L.) on 4NQO-induced mutagenesis in Escherichia coli WP2

Mutation Research
Y S ZhangY N Yu

Abstract

Aqueous extract prepared from garlic bulbs markedly suppressed the mutagenesis in both E. coli WP2 trp- and E. coli WP2 trp- uvrA- induced by 4-nitroquinoline 1-oxide (4NQO), but not that induced by UV. Cellular toxicity, inhibition of the expression of the Trp+ phenotype and delay of the first cell division after 4NQO treatment were not observed in the presence of the extract. Since the extract showed identical antimutagenic effects against 4NQO in both test strains but no effect on the mutagenesis of UV, it seems that the extract might act by inactivating the electrophilic group(s) of 4NQO or inhibiting its metabolic activation.

Citations

Oct 1, 1994·Clinical Biochemistry·B Stavric
Jan 16, 2002·Cancer Letters·Yogeshwer Shukla, Pankaj Taneja
May 8, 2003·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Saura C Sahu
Oct 24, 2001·Environmental Health Perspectives·F Bianchini, H Vainio
Feb 24, 2001·Drug Metabolism and Drug Interactions·A M Le Bon, M H Siess
Apr 26, 2000·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M AliM Afzal
Aug 23, 2021·Molecular and Cellular Biochemistry·Salim M A BastakiE Adeghate

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