Antimutagenic effects of cinnamaldehyde on chemical mutagenesis in Escherichia coli.

Mutation Research
T OhtaT Kada

Abstract

Antimutagenic effects of cinnamaldehyde on mutagenesis by chemical agents were investigated in Escherichia coli WP2 uvrA- trpE-. Cinnamaldehyde, when added to agar medium, greatly reduced the number of Trp+ revertants induced by 4-nitroquinoline 1-oxide (4-NQO) without any decrease of cell viability. This antimutagenic effect could not be explained by inactivation of 4-NQO caused by direct interaction with cinnamaldehyde. Mutagenesis by furylfuramide (AF-2) was also suppressed significantly. Mutations induced by methyl methanesulfonate (MMS) and ethyl methanesulfonate (EMS) were slightly inhibited. However, cinnamaldehyde was not at all effective on the mutagenesis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Two derivatives of cinnamaldehyde, cinnamyl alcohol and trans-cinnamic acid, did not have as strong antimutagenic effects on 4-NQO mutagenesis as cinnamaldehyde had. Because cinnamaldehyde showed marked antimutagenic effects against mutations induced by UV-mimic mutagens but not those induced by MNNG or EMS, it seems that cinnamaldehyde might act by interfering with an inducible error-prone DNA repair pathway.

References

Oct 12, 1979·Biochemical and Biophysical Research Communications·M YamadaT Sugimura
Nov 1, 1978·Mutation Research·B A Bridges, R P Mottershead
Jan 1, 1969·Annual Review of Microbiology·E M Witkin
Jan 1, 1980·Molecular & General Genetics : MGG·P F Schendel, M Defais

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Citations

Dec 1, 1988·Mutation Research·Y Kuroda, T Inoue
Jun 1, 1992·Mutation Research·Y KurodaT Kada
Jun 1, 1992·Mutation Research·L A MitscherG Stewart
Jan 1, 1990·Mutation Research·M D WatersH E Brockman
Sep 1, 1992·Mutation Research·T Neudecker
Feb 1, 1984·Mutation Research·H W Renner
Sep 1, 1987·Mutation Research·T Nunoshiba, H Nishioka
Jan 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T OhtaT Kada
Dec 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C D HébertM P Dieter
Oct 1, 1989·Journal of Ethnopharmacology·S SenA Sharma
Sep 1, 1989·Mutation Research·K WatanabeY Shirasu
Dec 1, 2012·Journal of Natural Products·Antonella Di SottoGabriela Mazzanti
Dec 15, 1985·Experientia·H MinakataT Kada
Apr 7, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C S LetiziaA M Api

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