Antimutagenic effects of ethanolic extracts from selected Palestinian medicinal plants

Journal of Ethnopharmacology
M KhaderP M Eckl

Abstract

Eryngium creticum, Nigella sativa, and Teucrium polium have been traditionally used for the treatment of inflammations, liver disorders, and arthritis. Various studies on these plants revealed anti-inflammatory, hepatoprotective and antimutagenic activities. Previous results of our research group, however, indicate that aqueous extracts prepared as for the traditional use (tea) have neither cytoprotective nor antimutagenic activity. Instead, there is evidence for a mutagenic potential. Since the described antimutagenic activity may not be present in effective amounts in the aqueous extracts this study focuses on ethanolic extracts. Ethanolic extracts of the three plant species were prepared and tested against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a directly acting mutagen. Since it cannot be excluded that the active constituents of the plant extracts require biotransformation or induce metabolic enzymes, causing antimutagenic or detoxifying effects, primary cultures of rat hepatocytes were used for this study. Plant ethanolic extracts were applied along with MNNG in three protocols: pre-treatment, combined treatment and post-treatment. The results of this investigation clearly indicate an inhibitory effect of the plant e...Continue Reading

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Citations

Jan 1, 2011·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Md Asaduzzaman KhanDian-zheng Zhang
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·M NgcoboN Gqaleni
Jan 27, 2016·Pharmaceutical Biology·Luiz Carlos Klein-JúniorAmélia Teresinha Henriques
Feb 22, 2012·Phytotherapy Research : PTR·Seifollah Bahramikia, Razieh Yazdanparast
Apr 14, 2016·Inflammopharmacology·M Akram Khan, M Afzal
Sep 22, 2016·Journal of Ayurveda and Integrative Medicine·Amin F Majdalawieh, Muneera W Fayyad
Feb 1, 2017·Critical Reviews in Food Science and Nutrition·Amin F MajdalawiehGheyath K Nasrallah
Feb 26, 2020·Biochemistry. Biokhimii︠a︡·E V StelmashookN K Isaev
Jul 4, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Muhammad ImranTanweer Aslam Gondal

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