Antimutagenic effects of lichen Pseudovernia furfuracea (L.) Zoph. extracts against the mutagenicity of aflatoxin B1 in vitro

Toxicology and Industrial Health
Hasan TurkezMustafa Anar

Abstract

The aim of this study was to investigate the effects of methanol, acetone, n-hexane and ether extracts obtained from Pseudovernia furfuracea on genotoxicity and total antioxidant capacity (TAC) in cultured human blood cells intoxicated with aflatoxin B(1) (AFB(1)). Sister chromatid exchange (SCE) and micronucleus (MN) tests were used for genotoxic influences estimation. In both the test systems, it was observed that P. furfuracea extracts suppressed the mutagenic effects of AFB(1) due to the type of extracts added to the cultures. Furthermore, a significant reduction in plasma TAC was observed after AFB(1) treatment. Interestingly, the methanol and acetone extracts of the lichen recovered AFB(1)-induced TAC inhibition. The order of extracts of anti-genotoxicity efficacy against AFB(1) was methanol, acetone, ether and n-hexane, respectively. In conclusion, P. furfuracea has been shown to modulate the adverse effects of AFB(1) in human blood cells for the first time.

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Citations

Nov 2, 2012·Toxicology and Industrial Health·Suat ColakGülşah Yıldız Deniz
Feb 10, 2012·Toxicology and Industrial Health·Hasan Turkez, Elanur Aydin
Jul 9, 2013·Toxicology and Industrial Health·Tülay Özhan BakırMurat Bakır
Nov 12, 2013·Toxicology and Industrial Health·Hasan Türkez, Elanur Aydın
Nov 7, 2013·Toxicology and Industrial Health·Gülşah Yıldız DenizAli Aslan
Jan 8, 2013·Toxicology and Industrial Health·Lokman AlpsoyAli Aslan
May 6, 2011·Toxicology and Industrial Health·Hasan Turkez, Ebubekir Dirican
Sep 14, 2011·Toxicology and Industrial Health·Hasan Türkez, Turgay Sisman
Apr 5, 2013·Toxicology and Industrial Health·Elanur AydinMevlüt Sait Keles
Feb 2, 2012·Toxicology and Industrial Health·Hasan Türkez, Başak Toğar
Nov 7, 2013·Toxicology and Industrial Health·Zühal PolatAli Aslan
Oct 2, 2013·Toxicology and Industrial Health·Hasan Türkez, Elanur Aydın
Nov 7, 2013·Toxicology and Industrial Health·Mustafa AnarGuleray Agar
Aug 9, 2012·Toxicology and Industrial Health·Hasan TurkezBaşak Togar
Oct 12, 2011·Toxicology and Industrial Health·Hasan Türkez, Elanur Aydin
May 31, 2021·Seminars in Cancer Biology·Tanvir Ul Hassan DarShafiul Haque

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